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From light to insight: Functional near-infrared spectroscopy for unravelling cognitive impairment during task performance.
Biosci Trends
January 2025
Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cognitive impairment refers to the impairment of higher brain functions such as perception, thinking or memory that affects the individual's ability to perform daily or social activities. Studies have found that changes in neuronal activity during tasks in patients with cognitive impairment are closely related to changes in cerebral cortical hemodynamics. Functional near-infrared spectroscopy is an indirect method to measure neural activity based on changes in blood oxygen concentration in the cerebral cortex.
View Article and Find Full Text PDFNeurological function is restored post-ischemic stroke in zebrafish, with aging exerting a deleterious effect on its pathology.
Brain Res Bull
January 2025
Graduate School of Pharmaceutical Science, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; Research Institute of Disaster Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan; Health and Disease Omics Center, Chiba University, Chiba, Japan. Electronic address:
Ischemic stroke (IS) is a pathological condition characterized by the cessation of blood flow due to factors such as thrombosis, inflicting severe damage to the cranial nervous system and resulting in numerous disabilities including memory impairments and hemiplegia. Despite the critical nature of this condition, therapeutic options remain limited, with a pressing challenge being the development of treatments aimed at restoring neurological function. In this study, we leveraged zebrafish, renowned for their exceptional regenerative capabilities, to analyze the pathology of IS and the subsequent recovery process.
View Article and Find Full Text PDFRevealing the therapeutic targets, mechanisms, and heterogeneity of Huatan Jieyu Granules for Parkinson's disease through single-cell sequencing.
J Pharm Biomed Anal
January 2025
Neurology Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address:
Background: The incidence of Parkinson's disease (PD) increases with age. Previous pharmacological studies have shown the potential of Huatan Jieyu Granules (HGs) for the treatment of PD, but the exact mechanisms remain unclear. This study aimed to explore the effects of herbal treatment on PD using mouse models and single-cell sequencing.
View Article and Find Full Text PDFRapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy.
Cell Death Discov
January 2025
Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
The neuromuscular junction (NMJ) is essential for transmitting signals from motor neurons (MNs) to skeletal muscles (SKMs), and its dysfunction can lead to severe motor disorders. However, our understanding of the NMJ is limited by the absence of accurate human models. Although human induced pluripotent stem cell (iPSC)-derived models have advanced NMJ research, their application is constrained by challenges such as limited differentiation efficiency, lengthy generation times, and cryopreservation difficulties.
View Article and Find Full Text PDFDifferential Coding of Fruit, Leaf, and Microbial Odours in the Brains of and .
Insects
January 2025
Centre for Mind/Brain Sciences (CIMeC), University of Trento, 38068 Rovereto, Italy.
severely damages the production of berry and stone fruits in large parts of the world. Unlike , which reproduces on overripe and fermenting fruits on the ground, prefers to lay its eggs in ripening fruits still on the plants. Flies locate fruit hosts by their odorant volatiles, which are detected and encoded by a highly specialised olfactory system before being translated into behaviour.
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