In the spleen, thymus and liver of mice and rats carrying transplantable rapidly growing hepatomas a shift between the de novo and "salvage" pathways of the pyrimidine RNA nucleotides synthesis in favour of the de novo one was observed. The phenomenon was found to be the manifestation of a drastically diminished uridine utilization by the host tissues, this precursor being preferentially and avidly used by the tumour for its own RNA synthesis. The above findings are regarded as the result of a successful competition of the tumour with the host tissues for vital metabolites representing one of the forms of the systemic effects of malignant neoplasms.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
In much of the northern Great Basin of the western United States, rangelands, and semi-arid ecosystems invaded by exotic annual grasses such as cheatgrass () and medusahead () are experiencing an increasingly short fire cycle, which is compounding and persistent. Improving and expanding ground-based field methods for measuring the above-ground biomass (AGB) may enable more sample collections across a landscape and over succession regimes and better harmonize with other remote sensing techniques. Developments and increased adoption of unoccupied aerial systems (UAS) and instrumentation for vegetation monitoring enable greater understanding of vegetation in many ecosystems.
View Article and Find Full Text PDFVulvar keratoacanthoma may be a malignant precursor: A case report and literature review.
Gynecol Oncol Rep
February 2025
People's Hospital of China Medical University, Department of Gynecology, People's Hospital of Liaoning Province, Shenyang, China.
Background: Keratoacanthoma is a relatively rare skin tumor, with vulvar keratoacanthoma being even more uncommon. Although the majority of keratoacanthomas exhibit a benign course, a subset of cases may show features of malignant potential, such as marginal invasion and recurrence.
Case: An 82-year-old female presented with a rapidly growing exophytic lesion on the left vulva, measuring 1.
Analysis of orthopaedic private healthcare patterns in England: A potential emerging two-tier system.
Public Health Pract (Oxf)
June 2025
Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Objectives: Private healthcare is a rapidly growing industry in the UK, particularly for surgical procedures, due to extensive waiting times in publicly funded health care. The NHS also commissions private healthcare to provide procedures for NHS patients to alleviate waiting times. We aimed to explore the trends and geographical variations between the North and South of England in privately funded and NHS-funded privately delivered orthopaedic procedures compared to NHS waiting times.
View Article and Find Full Text PDFRats and mice rapidly update timed behaviors.
Anim Cogn
January 2025
Neuroscience Department, Oberlin College, 173 Lorain St, Oberlin, OH, USA.
Keeping track of time intervals is a crucial aspect of behavior and cognition. Many theoretical models of how the brain times behavior make predictions for steady-state performance of well-learned intervals, but the rate of learning intervals in these models varies greatly, ranging from one-shot learning to learning over thousands of trials. Here, we explored how quickly rats and mice adapt to changes in interval durations using a serial fixed-interval task.
View Article and Find Full Text PDFPrescribing Psychostimulants for the Treatment of Stimulant Use Disorder: Navigating the Federal Legal Landscape.
J Addict Med
January 2025
From the Division of General Internal Medicine, San Francisco General Hospital, Department of Medicine, University of California San Francisco, San Francisco, CA (LWS); San Francisco Department of Public Health, San Francisco, CA (POC); Vital Strategies, New York, NY (KB, DC); Network for Public Health Law, Edina, MN (CSD); and New York University Grossman School of Medicine, New York, NY (CSD).
Stimulant use disorder (StUD) is a rapidly growing concern in the United States, with escalating rates of death attributed to amphetamines and cocaine. No medications are currently approved for StUD treatment, leaving clinicians to navigate off-label medication options. Recent studies suggest that controlled prescription psychostimulants such as dextroamphetamine, methylphenidate, and modafinil are associated with reductions in self-reported stimulant use, craving, and depressive symptoms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!