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Light Regulation of Insect Behavior by Azobenzene-modified Flonicamid as Novel Molecular Tools.
J Agric Food Chem
December 2024
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Photopharmacology, an emerging interdisciplinary field, enables precise modulation of target biological activity by employing light-controllable photoswitchable molecules. The research on nicotinamidase (Naam), a recently identified target molecule for pesticides, remains relatively underexplored. Therefore, based on the structure of its inhibitor Flonicamid, we designed and synthesized a series of photopharmacological ligands (FAB) by incorporating a light-controllable azobenzene switch, further investigating their effects on insect behavior and activity.
View Article and Find Full Text PDFIn silico studies on nicotinamide analogs as competitive inhibitors of nicotinamidase in methicillin-resistant Staphylococcus aureus.
Mol Divers
November 2024
Structural Biology & Bioinformatics Laboratory, Department of Biosciences, Manipal University Jaipur, Jaipur-Ajmer Express Highway, Jaipur, Rajasthan, 303007, India.
Nicotinamidase/PncA is a member of the hydrolase enzyme family, catalyzing the de-amidation of nicotinamide (NM) to nicotinic acid (NA) via salvage pathway. Products are fed into Preiss-Handler pathway for NAD biosynthesis which is an important enzyme cofactor and crucial for redox balance in microorganisms. Pathogens like methicillin-resistant Staphylococcus aureus (MRSA) are NAD auxotroph and rely on their host environment for NAD precursors to synthesize NAD.
View Article and Find Full Text PDF-derived vitamin B3 exerts protective effects against intestinal inflammation by promoting IL-17A/IL-22-dependent epithelial barrier function.
Gut Microbes
October 2024
Department of Life Science, National Taiwan University, Taipei, Taiwan.
a prevalent gut commensal fungus in healthy individuals - contributes to intestinal health and disease. However, how commensal influences intestinal homeostasis and barrier function is poorly understood. Here, we demonstrated that the reference strain of (MYA-3404) ameliorated intestinal inflammation in murine models of chemically induced colitis and bacterial infection.
View Article and Find Full Text PDFARV1 deficiency induces lipid bilayer stress and enhances rDNA stability by activating the unfolded protein response in Saccharomyces cerevisiae.
J Biol Chem
May 2024
School of Biological Sciences, Seoul National University, Seoul, Republic of Korea; Institute of Microbiology, Seoul National University, Seoul, Republic of Korea. Electronic address:
The stability of ribosomal DNA (rDNA) is maintained through transcriptional silencing by the NAD-dependent histone deacetylase Sir2 in Saccharomyces cerevisiae. Alongside proteostasis, rDNA stability is a crucial factor regulating the replicative lifespan of S. cerevisiae.
View Article and Find Full Text PDFIdentification of a mycobacterial hydrazidase, an isoniazid-hydrolyzing enzyme.
Sci Rep
May 2023
Department of Bacteriology, Osaka Metropolitan University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
There exists decades-old evidence that some mycobacteria, including Mycobacterium avium and Mycobacterium smegmatis, produce hydrazidase, an enzyme that can hydrolyze the first-line antitubercular agent isoniazid. Despite its importance as a potential resistance factor, no studies have attempted to reveal its identity. In this study, we aimed to isolate and identify M.
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