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A Novel Technique for the Topical Application of Botulinum Neurotoxin A to the Nasal Mucosa in Reducing Rhinitis Symptoms.
Cureus
December 2024
Anatomy, Yonsei University, Seoul, KOR.
Introduction: To date, no investigations have been published regarding the concentration, dose, and technique for a mucosal spray application of botulinum toxin A (BTA) to alleviate hypersecretory symptoms of rhinitis in humans. It is a promising option for reducing common symptoms of seasonal allergic rhinitis (AR) and idiopathic non-AR. It is safer and less painful than intranasal injections, with high reported satisfaction in reducing clinical symptoms.
View Article and Find Full Text PDFMinimal Clinically Important Differences With the Outcomes of the App-Based Japanese Allergic Conjunctival Diseases Quality of Life Questionnaire: Cross-Sectional Observational Study.
JMIR Form Res
November 2024
Department of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Background: Assessing changes in quality of life in patients with hay fever-related allergic conjunctivitis requires validated and clinically meaningful metrics. A minimal clinically important difference (MCID) that can be applied to assess Domain II of the Japanese Allergic Conjunctival Disease Quality of Life Questionnaire (JACQLQ) in a smartphone app setting has yet to be determined.
Objective: This cross-sectional observational study aimed to determine MCIDs for the app-based JACQLQ in assessing hay fever-related allergic conjunctivitis.
Prevalence Survey on Oral Allergy Syndrome in Patients With Seasonal Allergic Rhinitis in Yamanashi, Japan.
Allergy
November 2024
Department of Otolaryngology, Head and Neck Surgery, University of Yamanashi, Chuo, Japan.
Skin cancer diagnosis associated with asthma and hay fever: a nationwide cross-sectional study.
Arch Dermatol Res
September 2024
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA, USA.
Asthma is a respiratory disorder caused by airway inflammation which may worsen after allergen exposure. Recent cohort studies demonstrate a positive association between skin cancer and asthma or hay fever (allergy to outdoor allergens such as pollen). Nationally-representative data for adults in the United States remains limited.
View Article and Find Full Text PDFBlood and local eosinophil levels in chronic rhinitis: Observations during seasonal allergen exposure and non-exposure.
World Allergy Organ J
July 2024
Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Article Synopsis
- Allergic rhinitis (AR) is linked to type 2 inflammation, with eosinophils being key players in this process, yet their distribution across different rhinitis subtypes has not been extensively studied.
- A study involving 558 chronic rhinitis patients during the spring pollen season found that perennial AR (PAR) patients had the highest blood eosinophil levels and the worst symptoms, while seasonal AR (SAR) patients showed higher eosinophil levels in pollen season.
- Results indicated that greater blood eosinophil counts were associated with more severe nasal and ocular symptoms, as well as higher instances of asthma and allergic conjunctivitis, highlighting that eosinophil levels are influenced by both rhinitis subtype and allerg
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