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Tadalafil pretreatment attenuates doxorubicin-induced hepatorenal toxicity by modulating oxidative stress and inflammation in Wistar rats.
Toxicol Rep
December 2024
Department of Oral Pathology and Medicine, Faculty of Dentistry, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria.
Doxorubicin (DOX) is a widely used anticancer agent, but its clinical application is limited by significant off-target hepatorenal toxicity. Tadalafil (TAD), a selective phosphodiesterase-5 inhibitor used mainly for erectile dysfunction and pulmonary arterial hypertension, has shown potential in reducing oxidative stress. This study investigated TAD's chemoprotective effects and underlying mechanisms in DOX-induced hepatorenal toxicity in rats over 12 days.
View Article and Find Full Text PDFAnalysis of cardiohemodynamic and electrophysiological effects of morphine along with its toxicokinetic profile using the halothane-anesthetized dogs.
J Toxicol Sci
June 2024
Department of Pharmacology, Faculty of Medicine, Toho University.
Although morphine has been used for treatment-resistant dyspnea in end-stage heart failure patients, information on its cardiovascular safety profile remains limited. Morphine was intravenously administered to halothane-anesthetized dogs (n=4) in doses of 0.1, 1 and 10 mg/kg/10 min with 20 min of observation period.
View Article and Find Full Text PDFVisually evoked local field potential changes in the caudate nucleus are remarkably more frequent in awake, behaving cats than in anaesthetized animals.
Physiol Int
March 2024
1Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
Article Synopsis
- The study investigates the effects of halothane gas anesthesia on local field potentials (LFPs) in the caudate nucleus (CN) of cats, comparing anesthetized and awake animals.
- Significant reductions in LFP power changes during visual stimulation were observed in anesthetized cats across different frequency ranges, particularly in static stimuli.
- These findings highlight the importance of using awake, behaving animals for more accurate analyses of visually evoked neural signals.
Altered [Ca2+] Regulation in Cortical Neurons of Mice Susceptible to Malignant Hyperthermia: An In Vivo Study.
Anesthesiology
October 2023
Mount Sinai Medical Center, Miami, Florida (J.R.L.).
In vivo analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events.
J Toxicol Sci
July 2023
Department of Pharmacology, Faculty of Medicine, Toho University.
Long-term use of proton pump inhibitors (PPIs) is known to clinically induce hypomagnesemia, increasing the risk toward QT-interval prolongation and lethal ventricular arrhythmias, whereas PPIs can directly modulate cardiac ionic currents in the in vitro experiments. In order to fill the gap between those information, we assessed acute cardiohemodynamic and electrophysiological effects of sub- to supra-therapeutic doses (0.05, 0.
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