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Validation of a Simple HPLC/UV Method for Assay and In Vitro Release of Glycosaminoglycan from Pharmaceutical Formulations.
ACS Omega
December 2024
Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Bornova, Izmir 35040, Turkey.
This study encompasses the validation of a simple, rapid, and sensitive HPLC/UV method developed in accordance with the guidelines set by ICH Q2(R2) for obtaining the active pharmaceutical ingredient from the glycosaminoglycan family in topical formulations. Previous methods reported for analyzing glycosaminoglycans in semisolid formulations are relatively complex and time-consuming, involving extraction, purification, and derivatization. This developed analytical method allows for straightforward extraction of the active pharmaceutical ingredient from the matrix, enabling the direct injection of samples.
View Article and Find Full Text PDFSilver nanoparticles loaded with pomegranate peel extract and hyaluronic acid mediate recovery of cutaneous wounds infected with .
Front Cell Infect Microbiol
December 2024
Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
Smart innovative nanocomposites based on active ingredients and metallic nanoparticles with effective wound healing and antifungal properties are efficient in overcoming the limitations of traditional therapeutic products. Open wounds provide an ideal niche for colonization by () which poses substantial global health issues owing to delayed wound healing and disordered healing mechanisms. Therefore, proficient innovative therapies that control infection and promote wound healing are of imperative importance for the management of wounds and prevention of infection and possible complications.
View Article and Find Full Text PDFCompatibility of Active Pharmaceutical Ingredients in Cleoderm™: A Comprehensive Study for Enhanced Topical Dermatological Treatments.
Int J Pharm Compd
October 2024
Fagron BV, Rotterdam, The Netherlands.
Article Synopsis
- The study analyzes the stability and compatibility of active pharmaceutical ingredients in Cleoderm™, a cream aimed at treating various skin conditions like acne and dermatitis.
- Advanced methods like high-performance liquid chromatography (HPLC) were used to ensure that the ingredients maintain their efficacy under stress.
- Results showed that key ingredients remained stable over a designated shelf life of 180 days, confirming Cleoderm™ as a reliable option for customized dermatological therapies.
Hidden benefits of snail mucus: A natural skincare marvel.
Biomol Biomed
August 2024
Department of Plant Biology and Plant Biotechnology, Guru Nanak College (Autonomous), Chennai, India.
Dear Editor, From a scientific perspective, snail mucus, or snail secretion filtrate (SSF), has emerged as a significant discovery in dermatology and regenerative medicine. Several studies on mucus composition have illuminated its features in recent years, yet much remains unexplored. High-quality snail mucus contains adequate levels of active substances (e.
View Article and Find Full Text PDFA randomized, pilot trial comparing vaginal hyaluronic acid to vaginal estrogen for the treatment of genitourinary syndrome of menopause.
Menopause
September 2024
From the Department of Urogynecology, New York University Langone Health, New York, NY.
Article Synopsis
- This study aimed to compare the effectiveness of vaginal hyaluronic acid (HLA), a non-hormonal treatment, with vaginal estrogen for genitourinary syndrome of menopause (GSM).
- Women with GSM were randomly assigned to use either vaginal HLA or vaginal estrogen cream for 12 weeks, measuring improvements in various symptoms using different questionnaires.
- Results showed no significant differences in symptom improvement between the two treatments, suggesting that vaginal HLA might be a viable non-hormonal option for managing GSM.
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