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Electroacupuncture alleviates acute myocardial ischemic injury in mice by regulating the β adrenergic receptor and post-receptor protein kinase A signaling pathway.
Acupunct Med
December 2024
Institute of Acupuncture and Meridian, Anhui University of Chinese Medicine, Hefei, China.
Objective: To determine the effect of electroacupuncture (EA) on β-adrenergic receptor (β-AR) and post-receptor protein kinase A (PKA) signaling pathway after acute myocardial ischemia (MI).
Methods: An MI model was established by ligating the left anterior descending coronary artery of wild-type (WT) C57/BL and β-AR mice (heterozygous for β-AR gene deletion). EA treatment was administered at HT5-HT7 or LU9-LU8.
The Synergic Role of Actomyosin Architecture and Biased Detachment in Muscle Energetics: Insights in Cross Bridge Mechanism Beyond the Lever-Arm Swing.
Int J Mol Sci
June 2021
Center for Biosystems Dynamics Research, RIKEN, Suita 5650874, Japan.
Muscle energetics reflects the ability of myosin motors to convert chemical energy into mechanical energy. How this process takes place remains one of the most elusive questions in the field. Here, we combined experimental measurements of in vitro sliding velocity based on DNA-origami built filaments carrying myosins with different lever arm length and Monte Carlo simulations based on a model which accounts for three basic components: (i) the geometrical hindrance, (ii) the mechano-sensing mechanism, and (iii) the biased kinetics for stretched or compressed motors.
View Article and Find Full Text PDFExogenous Abscisic Acid Can Influence Photosynthetic Processes in Peas through a Decrease in Activity of H-ATP-ase in the Plasma Membrane.
Biology (Basel)
October 2020
Department of Biophysics, N.I. Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603950, Russia.
Article Synopsis
- Abscisic acid (ABA) is a plant hormone that helps plants cope with stress, and treatments with ABA or its analogs could enhance stress tolerance in agriculture.
- The study aimed to understand how ABA treatment affects photosynthesis and electrical signaling in pea plants, specifically looking at the role of inactivating the plasma membrane H-ATP-ase.
- Results showed that ABA treatment increased heat tolerance in photosynthesis while altering electron flow and reducing CO2 assimilation, indicating that changes in H-ATP-ase activity might explain how ABA affects these processes.
Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation.
Redox Biol
July 2020
Departamento de Fisiología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain. Electronic address:
AMP-activated protein kinase (AMPK) is a cellular energy sensor activated during energy stress to stimulate ATP production pathways and restore homeostasis. AMPK is widely expressed in the kidney and involved in mitochondrial protection and biogenesis upon acute renal ischemia, AMPK activity being blunted in metabolic disease-associated kidney disease. Since little is known about AMPK in the regulation of renal blood flow, the present study aimed to assess the role of AMPK in renal vascular function.
View Article and Find Full Text PDFMethylene blue stimulates substrate-level phosphorylation catalysed by succinyl-CoA ligase in the citric acid cycle.
Neuropharmacology
September 2017
Department of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 37-47 Tuzolto St., Budapest, 1094, Hungary. Electronic address:
Methylene blue (MB), a potential neuroprotective agent, is efficient in various neurodegenerative disease models. Beneficial effects of MB have been attributed to improvements in mitochondrial functions. Substrate-level phosphorylation (SLP) results in the production of ATP independent from the ATP synthase (ATP-ase).
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