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The Effects of Opioid-Free Anesthesia with Dexmedetomidine and Esketamine on Postoperative Anesthetic-Related Complications for Hip Surgery in the Elderly.
Int J Gen Med
December 2024
Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Purpose: The routine perioperative use of opioids has recently been questioned due to opioid-related side effects, which can be potentially harmful in geriatric patients. This study aimed to evaluate the effects of opioid-free anesthesia in geriatric patients undergoing hip surgery.
Patients And Methods: A total of 121 patients, aged 60 years or older, undergoing elective hip surgery were randomized to receive either opioid-free anesthesia with dexmedetomidine and esketamine (OFA group) or balanced anesthesia with opioids (CON group).
Response to comment on "High- versus low-dose ketamine for analgesia in older adults in the emergency department".
Am J Emerg Med
November 2024
Department of Emergency Medicine, Mayo Clinic, Rochester, MN, USA; Department of Medicine, Division of Community Internal Medicine, Geriatric Medicine and Palliative Care, Mayo Clinic, Rochester, MN, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
High- versus low-dose ketamine for analgesia in older adults in the emergency department.
Am J Emerg Med
December 2024
Department of Emergency Medicine, Mayo Clinic, Rochester, MN, USA; Department of Medicine, Division of Community Internal Medicine, Geriatric Medicine and Palliative Care, Mayo Clinic, Rochester, MN, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Background And Objectives: Ketamine is increasingly being utilized in the management of acute pain in the emergency department (ED), including for older adults, a population at increased risk of adverse effects from medications. We aimed to compare the safety and analgesic effects of high-dose (≥0.3mg/kg) to low-dose (<0.
View Article and Find Full Text PDFThe CB2-PKC pathway is involved in esketamine-induced anti-inflammation in BV-2 microglial cells exposed to lipopolysaccharides.
Am J Transl Res
September 2024
Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA Guangzhou 510501, Guangdong, China.
Article Synopsis
- Esketamine (ESK) is an intravenous anesthetic known to have antidepressant effects, but the exact mechanism behind this is not well understood.
- The study investigated the involvement of microglial cannabinoid type 2 (CB2) receptors and protein kinase C (PKC) in ESK's antidepressant action, using lipopolysaccharide (LPS) to induce neuroinflammation in microglial cells.
- Results showed that ESK reduced inflammation by lowering proinflammatory cytokines and nitrite levels, and that this effect was blocked when using a CB2 receptor antagonist or PKC inhibitor, indicating that the CB2-PKC pathway plays a key role in ESK's anti-inflammatory effects.
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