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Drug-induced hearing disorders: a disproportionality analysis of the FAERS database.
Front Pharmacol
November 2024
Department of Pharmacy, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.
Article Synopsis
- The study aimed to identify and evaluate reports of hearing impairment related to drugs approved in the last 20 years to enhance treatment safety.
- It analyzed adverse event data from the FAERS database and focused on "hearing disorders" to find potential new adverse reactions linked to specific medications.
- The findings highlighted the top five drugs most associated with hearing impairment incidents and identified new signals for drugs not previously linked to this side effect, indicating a need for caution with commonly prescribed medications.
Efficient Reversal of Neuromuscular Blocking Agent-Induced Biological Functions and Side Effects by an Extended Biphen[3]arene Carboxylate.
J Med Chem
December 2024
State Key Laboratory of National Security Specially Needed Medicines, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China.
Article Synopsis
- * A new compound called ExBP3C was developed as an effective reversal agent for multiple NMBAs, showing strong binding capabilities with agents like atracurium and rocuronium.
- * ExBP3C demonstrated better efficiency than the existing reversal drug sugammadex, and in tests, it rapidly corrected heart rate issues caused by an overdose of atracurium within two minutes, indicating good safety and biocompatibility.
Structure-Activity Relationship Studies Leading to the Discovery of Highly Water-Soluble and Biocompatible Acyclic Cucurbit[]uril FY-3451 as a Universal Antagonist That Rapidly Reverses Neuromuscular Blocking Agents .
J Med Chem
October 2024
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
Article Synopsis
- Researchers have created new acyclic cucurbit[]urils (acCBs) that can quickly reverse effects of common nondepolarizing neuromuscular blocking agents (NMBAs).
- The modified version (FY 3451) shows significantly improved activity and high water solubility, demonstrating effective results in animal studies with rats.
- At certain doses, FY 3451 outperforms existing reversal agent sugammadex in terms of recovery time from some NMBAs like rocuronium and cisatracurium.
The Dosage of Muscle Relaxants in Morbidly Obese Patients in Daily Practice - A Narrative Review.
Int J Gen Med
September 2024
Department of Anaesthesiology and Intensive Care, Regional Specialist Hospital in Olsztyn, Olsztyn, Poland.
The prevalence of morbid obesity in today's population around the world is alarming. Morbid obesity involves substantial changes in body composition and function, which can affect the pharmacodynamics and pharmacokinetics of many drugs. This paper aims to discuss the application of muscle relaxants and their reversing agents in patients with morbid obesity.
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