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Chromatographic analysis and pK evaluation of active pharmaceutical ingredients in anti-metastatic breast cancer: Green vs. conventional RPLC.
J Pharm Biomed Anal
January 2025
Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul 34956, Turkey.
This study aimed to determine the chromatographic retention and dissociation/protonation constant (pK) values of lapatinib and tamoxifen, key drugs used in metastatic breast cancer treatment, at 37°C using both conventional and green high-performance liquid chromatography (HPLC) methods. Qualitative analysis was conducted on an XTerra C18 column (250 ×4.6 mm I.
View Article and Find Full Text PDFCO-driven ion exchange for ammonium recovery from source-separated urine.
Water Res
January 2025
Georgia Tech Shenzhen Institute (GTSI), Tianjin University, Shenzhen 518067, China. Electronic address:
Nitrogen recovery from urine and CO utilization are both vital for achieving a circular economy and mitigating climate change. Divided engineering solutions have been proposed to address either problem, but there is still a lack of integrated technologies to simultaneously tackle the two tasks. We demonstrated CO-driven ion exchange for nitrogen recovery (CIXNR) from urine and evaluated the process in Malawi.
View Article and Find Full Text PDFMetabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity.
Crit Care
January 2025
Department of Critical Care Medicine, Cumming School of Medicine, Health Research Innovation Center (HRIC), University of Calgary, Room 4C64, 3280 Hospital Drive N.W., Calgary, AB, T2N 4Z6, Canada.
Background: Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic brain injury (sTBI), although it accounts for only 10% of all TBI cases, results in a mortality rate of 30-40% and a significant burden of disability in those that survive. This study explored the potential of metabolomics in the diagnosis of sTBI and explored the potential of metabolomics to examine probable primary and secondary brain injury in sTBI.
View Article and Find Full Text PDFElemental cryo-imaging reveals SOS1-dependent vacuolar sodium accumulation.
Nature
January 2025
Laboratory for Biological Geochemistry, School of Architecture, Civil and Environmental Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Increasing soil salinity causes significant crop losses globally; therefore, understanding plant responses to salt (sodium) stress is of high importance. Plants avoid sodium toxicity through subcellular compartmentation by intricate processes involving a high level of elemental interdependence. Current technologies to visualize sodium, in particular, together with other elements, are either indirect or lack in resolution.
View Article and Find Full Text PDFVonoprazan Fumarate: A Promising Therapeutic Option for the Rapid Relief of Laryngopharyngeal Reflux Disease.
J Voice
January 2025
Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China; The First College of Clinical Medicine, Xuzhou Medical University, Xuzhou, China. Electronic address:
Objective: The aim is to examine the Reflux Symptom Score-12 (RSS-12) and assess the effectiveness of vonoprazan fumarate in managing laryngopharyngeal reflux disease (LPRD) among the Chinese population.
Methods: A total of 140 patients with LPRD who were treated at our otorhinolaryngology outpatient clinic were included. The patients were randomly divided into the vonoprazan treatment group and the esomeprazole treatment group.
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