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Doxycycline post-exposure prophylaxis for preventing bacterial sexually transmitted infections (STIs): Are clinical providers supportive?
Int J STD AIDS
December 2024
New York State Department of Health AIDS Institute, Albany, NY, USA.
Background: Bacterial sexually transmitted infections (STIs) continue to increase in the United States. Despite evidence of the effectiveness of doxycycline post-exposure prophylaxis (Doxy-PEP) to prevent STIs, little is known about providers' attitudes and willingness to implement Doxy-PEP.
Methods: An online questionnaire was sent to 575 clinical providers in New York State in September 2022.
Measurements of neurite extension and nucleokinesis in an iPSC-derived model system following microtubule perturbation.
Mol Biol Cell
January 2025
Department of Biology, McGill University, Montréal, Québec H3A 1B1, Canada.
In neurons, patterns of different microtubule types are essential for neurite extension and nucleokinesis. Cellular model systems such as rodent primary cultures and induced pluripotent stem cells (iPSC)-derived neurons have provided key insights into how these patterns are created and maintained through the action of microtubule-associated proteins, motor proteins, and regulatory enzymes. iPSC-derived models show tremendous promise but lack benchmarking and validation relative to rodent primary cultures.
View Article and Find Full Text PDFSynthesis and Antibacterial Activity of Alkylamine-Linked Pleuromutilin Derivatives.
Antibiotics (Basel)
October 2024
School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
In an effort to expand the spectrum of the antibacterial activity of pleuromutilin, a series of amine- and polyamine-linked analogues were prepared and evaluated for activities against a panel of microorganisms. Simple C-22-substituted amino esters or diamines , , , and , as well as two unusual amine-linked bis-pleuromutilin examples and , displayed variable levels of activity towards ATCC 25923 and methicillin-resistant , but with no detectable activities towards Gram-negative bacteria. Fortunately, the incorporation of a longer-chain triamine or polyamine (spermine) at C-22 did afford analogues (, ) that exhibited activity towards both ATCC 25923 and ATCC 25922 with MIC 6.
View Article and Find Full Text PDFTetracyclines Revisited: Tetracyclines in the Field of Dermatology.
Dermatology
December 2024
Department of Dermatology, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Article Synopsis
- * The review discusses various conditions such as hidradenitis suppurativa, vitiligo, and atopic dermatitis, highlighting the diverse applications of tetracyclines in dermatology.
- * It also examines sarecycline, a new narrow-spectrum tetracycline, emphasizing its clinical effectiveness and potential effects on the microbiome, advocating for a broader use of tetracyclines in treating skin disorders.
The effect of early administration of antibiotics or feeding a diet containing coccidiostats on the level of their accumulation in liver and the redox status of turkeys.
Animal
October 2024
Department of Biochemistry and Toxicology, University of Life Sciences, Akademicka 13, 20-950 Lublin, Poland.
Article Synopsis
- Early administration of antibiotics in turkeys may impair their antioxidant function and raise concerns about liver accumulation, particularly with longer antibiotic use.
- The study involved 3,080 female turkeys divided into eight groups to assess the effects of different antibiotic treatments and vaccinations on liver accumulation and antioxidant system health.
- Results indicated that while enrofloxacin and doxycycline were metabolized in the liver with lower than maximum residue levels, monensin levels increased over time, suggesting a risk of accumulation close to slaughter.
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