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Intracellular islatravir-triphosphate half-life supports extended dosing intervals.
Antimicrob Agents Chemother
September 2024
Merck & Co., Inc., Rahway, New Jersey, USA.
Antiretroviral therapy has substantially reduced morbidity, mortality, and disease transmission in people living with HIV. Islatravir is a nucleoside reverse transcriptase translocation inhibitor that inhibits HIV-1 replication by multiple mechanisms of action, and it is in development for the treatment of HIV-1 infection. In preclinical and clinical studies, islatravir had a long half-life (t) of 3.
View Article and Find Full Text PDF[Pathogenetic basis of optic nerve atrophy in methanol poisoning].
Vestn Oftalmol
May 2024
Kazan State Medical University, Kazan, Russia.
Optic nerve atrophy is a pathomorphological consequence of diseases of the peripheral neuron of the visual pathway, manifested as atrophy of nerve fibers of varying severity. The toxic effect of methanol is mainly associated with formic acid and formaldehyde, which suppress the cytochrome system, inhibit oxidative phosphorylation, and thereby cause a deficiency of adenosine triphosphoric acid, to which brain and retinal tissues are especially susceptible. When formiate accumulates, tissue respiration is disrupted, leading to pronounced tissue hypoxia.
View Article and Find Full Text PDFEnhancement of skin rejuvenation and hair growth through novel near-infrared light emitting diode (nNIR) lighting: in vitro and in vivo study.
Lasers Med Sci
April 2024
Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
The study aimed to explore the impact of a novel near-infrared LED (nNIR) with an extended spectrum on skin enhancement and hair growth. Various LED sources, including White and nNIRs, were compared across multiple parameters: cytotoxicity, adenosine triphosphate (ATP) synthesis, reactive oxygen species (ROS) reduction, skin thickness, collagen synthesis, collagenase expression, and hair follicle growth. Experiments were conducted on human skin cells and animal models.
View Article and Find Full Text PDFEndothelin-1-mediated Brainstem Glial Activation Produces Asthmatic Airway Vagal Hypertonia Via Enhanced ATP-P2X4 Receptor Signaling in Sprague-Dawley Rats.
J Neuroimmune Pharmacol
April 2024
Department of Physiology and Pathophysiology, Fudan University School of Basic Medical Sciences, 130 Dong'an Rd., 207 Seventh Building, West Campus, Shanghai, 200032, China.
The occurrence of major asthma symptoms is largely attributed to airway vagal hypertonia, of which the central mechanisms remain unclear. This study tests the hypotheses that endothelin-1-mediated brainstem glial activation produces asthmatic airway vagal hypertonia via enhanced action of adenosine 5'-triphosphate on neuronal purinergic P2X4 receptors. A rat model of asthma was prepared using ovalbumin.
View Article and Find Full Text PDFA microfluidic chip-based capillary zone electrophoresis-mass spectrometry method for measuring adenosine 5'-Triphosphate and its similar nucleotide analogues.
Anal Chim Acta
April 2024
Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA. Electronic address:
Article Synopsis
- - The study highlights a novel method using microfluidic chip-based capillary zone electrophoresis-mass spectrometry (μCZE-MS) for the simultaneous measurement of ATP and its analogues in biological fluids, addressing limitations of traditional methods.
- - It successfully employed a novel ZipChip Interface to separate and identify nucleotide standards, ATP, ADP, AMP, and adenosine in plasma and BALF from rats, demonstrating quick and direct detection capabilities while emphasizing the need to protect these molecules using chelators like EDTA.
- - The μCZE-MS method is not only effective for nucleotide analysis but also shows promise for metabolite detection, suggesting its potential for advancing research on extracellular ATP in diseases and developing ATP-target
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