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Topographic Patterns of Intracranial Meningioma Recurrences-Systematic Review with Clinical Implication.
Cancers (Basel)
June 2024
Department of Neurosciences, Reproductive and Odontostomatological Sciences, Neurosurgical Division, Università di Napoli Federico II, 80131 Naples, Italy.
Background: While several risk factors for recurrences have been defined, the topographic pattern of meningioma recurrences after surgical resection has been scarcely investigated. The possibility of theoretically predicting the site of recurrence not only allows us to better understand the pathogenetic bases of the disease and consequently to drive the development of new targeted therapies, but also guides the decision-making process for treatment strategies and tailored follow-ups to decrease/prevent recurrence.
Methods: The authors performed a comprehensive and detailed systematic literature review of the EMBASE and MEDLINE electronic online databases regarding the topographic pattern of recurrence after surgical treatment for intracranial meningiomas.
This study is aimed at investigating epileptic seizures, one of the consequences of traumatic brain injury (TBI). Immediate and early post-traumatic seizures, as well as late post-traumatic epileptic seizures or post-traumatic epilepsy, can have different pathogenetic bases. The following key risk factors associated with post-traumatic epilepsy are known: duration of unconsciousness, gunshot wounds, intracranial hemorrhage, diffuse axonal injury, prolonged (more than 3 days) post-traumatic amnesia, acute subdural hematoma with surgical evacuation, immediate and early post-traumatic epileptic seizures, fracture of the skull bones.
View Article and Find Full Text PDFThe PANDAS/PANS disorders. Is it time for more allergist-immunologists to get involved?
Allergy Asthma Proc
September 2023
From the Department of Pediatrics.
The pediatric autoimmune neurologic disorders associated with streptococcal infections (PANDAS) comprise a group of patients who, after infection with group A β-hemolytic streptococci (GAS), exhibit a spectrum of neuropsychiatric symptoms that include obsessive thoughts, compulsive behaviors, tics, hyperactivity, inattention, and mild choreiform movements. More recently, a group of patients with a symptom complex similar to PANDAS without evidence of streptococcal etiology was given the acronym pediatric acute-onset neuropsychiatric syndrome (PANS). Despite more than several decades of study and increasing numbers of patients being identified with PANDAS and PANS, there are ongoing controversies, which range from disagreements about specific pathogenetic mechanisms to whether these entities actually exist.
View Article and Find Full Text PDFTreatable Traits in Systemic Sclerosis.
Clin Rev Allergy Immunol
October 2023
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Article Synopsis
- Systemic sclerosis (SSc) is a complex, chronic disease affecting connective tissues, marked by issues in blood vessels and inflammation/fibrosis in the skin and organs, leading to high levels of illness and death.
- The varying clinical features of SSc make it essential to analyze autoantibodies and skin involvement to better predict patient risks and tailor treatments effectively.
- The text promotes a "treatable trait" approach, which emphasizes personalized medicine using specific biomarkers and mechanisms of tissue damage to improve management and outcomes for SSc patients.
Genetic bases of C7 deficiency: systematic review and report of a novel deletion determining functional hemizygosity.
Front Immunol
June 2023
Department of Life Sciences, University of Trieste, Trieste, Italy.
Primary complement system (C) deficiencies are rare but notably associated with an increased risk of infections, autoimmunity, or immune disorders. Patients with terminal pathway C-deficiency have a 1,000- to 10,000-fold-higher risk of infections and should be therefore promptly identified to minimize the likelihood of further infections and to favor vaccination. In this paper, we performed a systematic review about clinical and genetic patterns of C7 deficiency starting from the case of a ten-year old boy infected by and with clinical presentation suggestive of reduced C activity.
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