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Structure-Activity Relationship Studies Leading to the Discovery of Highly Water-Soluble and Biocompatible Acyclic Cucurbit[]uril FY-3451 as a Universal Antagonist That Rapidly Reverses Neuromuscular Blocking Agents .
J Med Chem
October 2024
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032, China.
Article Synopsis
- Researchers have created new acyclic cucurbit[]urils (acCBs) that can quickly reverse effects of common nondepolarizing neuromuscular blocking agents (NMBAs).
- The modified version (FY 3451) shows significantly improved activity and high water solubility, demonstrating effective results in animal studies with rats.
- At certain doses, FY 3451 outperforms existing reversal agent sugammadex in terms of recovery time from some NMBAs like rocuronium and cisatracurium.
The Influence of Acid-Base Balance on Anesthetic Muscle Relaxants: A Comprehensive Review on Clinical Applications and Mechanisms.
Med Sci Monit
July 2024
Department Anaesthesiology and Intensive Care, Faculty of Medicine, Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
Muscle relaxants have broad application in anesthesiology. They can be used for safe intubation, preparing the patient for surgery, or improving mechanical ventilation. Muscle relaxants can be classified based on their mechanism of action into depolarizing and non-depolarizing muscle relaxants and centrally acting muscle relaxants.
View Article and Find Full Text PDFExtravascular injection of neuromuscular blocking drugs: A systematic review of current evidence and management.
Eur J Anaesthesiol
May 2024
From the Department of Anaesthesiology, UZ Leuven, Leuven, Belgium (FN, VG), Department of Anaesthesiology, Ziekenhuis Oost-Limburg, Genk, Belgium (IVH) and Department of Anaesthesiology, AZ Turnhout, Turnhout, Belgium (FS).
Extravascular injection of neuromuscular blocking drugs (NMBDs) can cause a neuromuscular block because of systemic absorption. Currently, there are no guidelines available on managing extravasation of NMBDs. This article reviews the available literature on extravasation of NMBDs.
View Article and Find Full Text PDFUnder-dosing and over-dosing of neuromuscular blocking drugs and reversal agents: beware of the risks.
Br J Anaesth
March 2024
Department of Anaesthesiology and Intensive Care Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany; Department of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine, University of Ulm, Ulm, Germany.
The phenomena of residual curarisation and recurarisation after the use of long-acting non-depolarising neuromuscular blocking drugs such as tubocurarine and pancuronium were well recognised 60 years ago. But the incidence seemed to decline with the introduction of atracurium and vecuronium. However, recently there have been an increasing number of reports of residual and recurrent neuromuscular block.
View Article and Find Full Text PDFPancuronium Bromide for Chemical Immobilization of Adult Nile Crocodiles (): A Field Study.
Animals (Basel)
May 2023
Djerba Explore Park, Djerba Midoun 4116, Tunisia.
(1) Background: Pancuronium bromide is a neuromuscular blocker used for immobilizing crocodiles that can be reversed with neostigmine. A recommended drug dose has only been established for saltwater crocodiles (), mostly based on trials in juveniles and subadults. After trialing a dose recommendation in a small cohort of nine Nile crocodiles (), we developed and applied a new dose recommendation for large adult Nile crocodiles.
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