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Tetracyclines cause cell stress-dependent ATF4 activation and mTOR inhibition.
Exp Cell Res
January 2014
Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, Munich, Germany.
Tetracyclines have long been used as valuable broad-spectrum antibiotics. The high antibacterial activity of tetracyclines, combined with their good tolerability, has led to their widespread use in treating various infectious diseases. However, similar to other antibiotics, tetracyclines are also known for their adverse effects on different human tissues, including hepatic steatosis.
View Article and Find Full Text PDFBackground: Cyclophosphamide is a potent anticancer drug, but its clinical utility is limited because of its severe side effects, in particular liver damage. Chalone 19-peptide induces apoptosis of tumor cells and inhibits tumor growth. The present study investigated the antitumor effects of a combination of cyclophosphamide and Chalone 19-peptide in experimental breast cancer.
View Article and Find Full Text PDFTransforming growth factor-beta: the elusive hepatic chalone?
Hepatology
July 1992
Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom.
Partially purified antichalone and chalone from the liver of the mammals possess significant antiradical activity revealed by the chemiluminiscent analysis in the system capable of generating free radicals. Chemiluminiscent damping degree is proportional to the quantity of antichalone and chalone in the system. During the first three days the activity of antichalone is increased, while that of chalone in decreased in the liver of partially hepatectomized rats.
View Article and Find Full Text PDFIn the work there was studied the influence of hepatic chalones on the level of mitotic activity and on the degree of adhesion of hepatocytes after the violation of parasympathetic and sympathetic innervation under the physiological conditions of liver function and in regenerating organ. Some definite regularities were revealed in the change of the power of linkage among the cells of liver parenchyma after the disturbance of its innervation and chalones affected. Significant differences in the effect of the influence of tissue inhibitors of proliferation on the process of regeneration in liver, which has intact or disturbed innervation were discovered.
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