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Are You My Host? An Overview of Methods Used to Link Bacteriophages with Hosts.
Viruses
January 2025
Department of Biology and Toxicology, Ashland University, Ashland, OH 44805, USA.
Until recently, the only methods for finding out if a particular strain or species of bacteria could be a host for a particular bacteriophage was to see if the bacteriophage could infect that bacterium and kill it, releasing progeny phages. Establishing the host range of a bacteriophage thus meant infecting many different bacteria and seeing if the phage could kill each one. Detection of bacterial killing can be achieved on solid media (plaques, spots) or broth (culture clearing).
View Article and Find Full Text PDFCharacterization of Phage Endolysin PlyDolk21.
Antibiotics (Basel)
January 2025
Department of Food Science and Biotechnology, Research Institute of Food and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
is a significant cause of food poisoning. Broad-spectrum antibiotics, commonly used to control , are becoming less effective due to the rise of antibiotic-resistant strains, necessitating alternative control strategies. A -infecting bacteriophage, Dolk21, and its endolysin, PlyDolk21, were isolated and characterized.
View Article and Find Full Text PDFIsolation of phages infecting the zoonotic pathogen reveals novel structural and genomic characteristics.
bioRxiv
January 2025
APC Microbiome Ireland, University College Cork, Co. Cork, T12 YT20, Ireland.
Bacteriophage research has experienced a renaissance in recent years, owing to their therapeutic potential and versatility in biotechnology, particularly in combating antibiotic resistant-bacteria along the farm-to-fork continuum. However, certain pathogens remain underexplored as targets for phage therapy, including the zoonotic pathogen which causes infections in pigs and humans. Despite global efforts, the genome of only one infective phage has been described.
View Article and Find Full Text PDFStructural variants of AcrIIC5 inhibit Cas9 via divergent binding interfaces.
Structure
January 2025
Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, South Korea; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, South Korea. Electronic address:
CRISPR-Cas is a bacterial defense system that employs RNA-guided endonucleases to destroy invading foreign nucleic acids. Bacteriophages produce anti-CRISPR (Acr) proteins to evade CRISPR-Cas defense during the infection. AcrIIC5, a type II-C Cas9 inhibitor, exhibits unusual variations in the local backbone fold between its orthologs.
View Article and Find Full Text PDFUsing BW25113 as a host, we isolated a novel lytic phage from the commercial poly-specific therapeutic phage cocktail Sextaphage (Microgen, Russia). We provide genetic and phenotypic characterization of the phage and describe its host range on the ECOR collection of reference strains. The phage, hereafter named Sxt1, is a close relative of classical coliphage T3 and belongs to the genus, yet its internal virion proteins, forming an ejectosome, differ from those of T3.
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