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BTKi-induced cardiovascular toxicity in CLL: Risk mitigation and management strategies.
Blood Rev
January 2025
Clinic of Hematology, University Clinical Centre of Serbia, Serbia; Faculty of Medicine, University of Belgrade, Serbia. Electronic address:
Targeted therapies, consisting of Bruton tyrosine kinase inhibitors (BTKis) or BCL-2 inhibitors, are the mainstay of contemporary treatments for chronic lymphocytic leukemia (CLL). The most common adverse effects (AEs) of BTKis are fatigue, bruising, infection, hematological and cardiovascular AEs. While AEs during treatment are usually mild (grades 1 and 2), grade 3 and 4 AEs have been detected in some patients, necessitating additional medical care and temporary or permanent drug discontinuation.
View Article and Find Full Text PDFImpact of probiotic treatment on clinical symptom reduction in schizophrenia: A systematic review and meta-analysis.
J Psychiatr Res
January 2025
Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain; CIBERSAM-ISCIII (Biomedical Research Networking Centre for Mental Health/Carlos III Health Institute), Spain; Department of Legal Medicine, Psychiatry, and Pathology. Complutense University of Madrid, Madrid, Spain. Electronic address:
Introduction: Recent research has identified gut microbiota dysbiosis as a potential contributing factor in schizophrenia, leading to growing interest in exploring probiotics as a complementary approach to traditional antipsychotic treatments. This study aims to systematically evaluate the current evidence on the efficacy of probiotics in improving clinical symptoms of schizophrenia, offering a novel perspective into their potential role as an adjunctive strategy.
Methods: A systematic search was conducted to review randomized clinical trials, adhering to the PRISMA guidelines.
Change point detection in brucellosis time series from 2010 to 2023 in Xinjiang China using the BEAST algorithm.
Sci Rep
January 2025
College of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830017, China.
Brucellosis is a significant global challenge, but there has been a lack of epidemiological studies on brucellosis in Xinjiang from a change point perspective. This study aims to bridge this gap by employing sequence decomposition and identifying significant change points, with datasets sourced from the Xinjiang Disease Prevention and Control Information System. This study employed the BEAST algorithm to decompose the brucellosis time series in Xinjiang from 2010 to 2023, while simultaneously identifying change points in the decomposed seasonal and trend components.
View Article and Find Full Text PDFCritical Review of Ketogenic Diet Throughout the Cancer Continuum for Neuroglioma: Insights from a Medical Nutrition Therapy (MNT) Perspective.
Curr Nutr Rep
January 2025
Department of Vascular Surgery, Mount Sinai Hospital, 1468 Madison Ave, New York, NY, 10029, USA.
PURPOSE OF REVIEW: A Ketogenic diet (KD; a diet comprised of 75% fat, 20% protein and 5% carbohydrates) has gained much popularity in recent years, especially regarding neurogliomas (or "gliomas"). This review critically assesses literature on the application of KD throughout the cancer continuum from a Medical Nutrition Therapy (MNT) perspective. RECENT FINDINGS: 2021 revised classification standards for Central Nervous System (CNS) tumors are available.
View Article and Find Full Text PDFTen proposed measures to improve vaccination: Health care providers' perspectives on promoting the vaccination intake of children with special healthcare needs in China.
BMJ Paediatr Open
January 2025
Department of Infectious Disease, Children's Hospital of Fudan University, National Children's Medical Center (Shanghai), Shanghai, China
Introduction: Children with special healthcare needs (CSHCN) often experience vaccination delays or missed vaccines in China. The coverage rate of the age-appropriate National Immunisation Programme vaccine was suboptimal. This study aimed to explore attitudes, behaviours, and suggestions regarding the improvement of routine vaccination services for CSHCN among healthcare providers.
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