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Small extracellular vesicles derived from sequential stimulation of canine adipose-derived mesenchymal stem cells enhance anti-inflammatory activity.
BMC Vet Res
January 2025
Center of Excellence for Veterinary Clinical Stem Cells and Bioengineering, Chulalongkorn University, Bangkok, 10330, Thailand.
Background: Small extracellular vesicles (sEVs) derived from mesenchymal stem cells (MSCs) are recognized for their therapeutic potential in immune modulation and tissue repair, especially in veterinary medicine. This study introduces an innovative sequential stimulation (IVES) technique, involving low-oxygen gas mixture preconditioning using in vitro fertilization gas (IVFG) and direct current electrical stimulation (ES20), to enhance the anti-inflammatory properties of sEVs from canine adipose-derived MSCs (cAD-MSCs). Initial steps involved isolation and comprehensive characterization of cAD-MSCs, including morphology, gene expression, and differentiation potentials, alongside validation of the electrical stimulation protocol.
View Article and Find Full Text PDFCompletely Multipolar Model for Many-Body Water-Ion and Ion-Ion Interactions.
J Phys Chem Lett
January 2025
Kenneth S. Pitzer Theory Center and Department of Chemistry, University of California, Berkeley, California 94720, United States.
This work constructs an advanced force field, the Completely Multipolar Model (CMM), to quantitatively reproduce each term of an energy decomposition analysis (EDA) for aqueous solvated alkali metal cations and halide anions and their ion pairings. We find that all individual EDA terms remain well-approximated in the CMM for ion-water and ion-ion interactions, except for polarization, which shows errors due to the partial covalency of ion interactions near their equilibrium. We quantify the onset of the dative bonding regime by examining the change in molecular polarizability and Mayer bond indices as a function of distance, showing that partial covalency manifests by breaking the symmetry of atomic polarizabilities while strongly damping them at short-range.
View Article and Find Full Text PDFPerceived Discrimination in the Healthcare Setting and Medical Mistrust: Findings from the Health Information National Trends Survey, 2022.
J Gen Intern Med
January 2025
Division of Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Background: Perceived discrimination and medical mistrust are barriers to care that impact both individual and population health.
Objective: This study aims to characterize the prevalence of perceived racial or ethnic discrimination in healthcare as well as mistrust in the medical system and explore their associations with race and ethnicity.
Design: Cross-sectional study of nationally representative data from the Health Information National Trends Survey (fielded March-November 2022).
Surface-modified carbon quantum dot for enhanced fluorescent-sensing of hexagonal valent chromium.
Anal Sci
January 2025
MOE Key Laboratory of Resources and Environmental System Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing, 102206, People's Republic of China.
As one of the most harmful heavy metal pollutants, hexavalent chromium Cr(VI) is becoming a serious threat to human health. Thus pursuing a remarkably sensitive method to monitor the Cr(VI) concentration in natural conditions is favored for the fast response to prevent harm. In the present work, an ethylenediamine (En) and SiO-modified wool keratin-based carbon quantum dot (CQD)(En@CQDs@SiO) fluorescent sensor is prepared, and the En is found to improve the discrimination ability by binding the Cr(VI) with the surface carboxyl groups.
View Article and Find Full Text PDFThe boost of force in unfused tetanic contractions at variable interpulse intervals in fast motor units of the rat medial gastrocnemius.
Sci Rep
January 2025
Department of Neurobiology, Poznan University of Physical Education, Poznan, Poland.
Previously, boost and sag effects seen in unfused tetanic contractions have been studied exclusively at constant stimulation frequency. However, intervals between successive discharges of motoneurons vary during voluntary movements. We therefore aimed to test whether the extra-efficient force production at the onset of contraction (boost) occurs during stimulation with variable intervals, and to what extent it depends on the level of interpulse interval (IPI) variability and history of stimulation.
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