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Cooperation Between Platelet β1 and β3 Integrins in the Arrest of Bleeding Under Inflammatory Conditions in Mice-Brief Report.
Arterioscler Thromb Vasc Biol
October 2024
Institut national de la santé et de la recherche médicale (INSERM), EFS (Etablissement français du sang) Grand Est, BPPS (Biologie et pharmacologie des plaquettes sanguines: hémostase, thrombose, transfusion) UMR (Unité mixte de recherche)-S1255, FMTS (Fédération de médecine translationnelle de Strasbourg), Université de Strasbourg, France (E.J.-B., N.R., L.M., C.M., S.M., F.L., B.H., P.H.M.).
Article Synopsis
- Platelets play a crucial role in stopping bleeding during inflammation, but their behavior can change based on the specific context and the receptors involved, particularly β1 and β3 integrins.
- In experiments with mice, those lacking β3 integrins showed bleeding in various inflammation models, while those lacking β1 integrins did not, indicating that β3 is more critical for hemostasis.
- The study concluded that the necessity and interplay between β1 and β3 integrins in managing bleeding during inflammation are influenced by the type of inflammatory scenario encountered.
Alisol B 23-Acetate Ameliorates Ovalbumin-Induced Allergic Asthma during Sensitization and Challenge Periods.
Biomol Ther (Seoul)
November 2023
Department of Pharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 02446, Republic of Korea.
Rhizome of has been used as a traditional medicine for treating kidney diseases in East Asian countries. Its inhibitory effects on hypersensitivity responses have been reported for methanol extracts, with alisol B 23-acetate (AB23Ac) being the most active constituent among six terpenes in inhibiting the direct passive Arthus reaction. However, whether AB23Ac has efficacy against allergic asthma has not been tested to date.
View Article and Find Full Text PDFCharacterization of the Role of Integrin α5β1 in Platelet Function, Hemostasis, and Experimental Thrombosis.
Thromb Haemost
May 2022
Université de Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S1255, FMTS, Strasbourg, France.
Objective: Integrins are key regulators of various platelet functions. The pathophysiological importance of most platelet integrins has been investigated, with the exception of α5β1, a receptor for fibronectin. The aim of this study was to characterize the role of α5β1 in megakaryopoiesis, platelet function, and to determine its importance in hemostasis and arterial thrombosis.
View Article and Find Full Text PDFTLT-1-CONTROLS EARLY THROMBUS FORMATION AND STABILITY BY FACILITATING AIIBB3 OUTSIDE-IN SIGNALING IN MICE.
Int J Adv Res (Indore)
March 2018
University of Puerto Rico-Rio Piedras, Department of Biology.
Platelets regulate inflammation as well as hemostasis. Inflammatory insults often induce hemostatic function through mechanisms that are not always understood. The triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is an abundantly expressed platelet receptor and its deletion leads to hemorrhage and edema after lipopolysaccharide and TNF-α treatment.
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