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Evidence for targeting autonomic dysfunction in systemic sclerosis: A scoping review.
J Scleroderma Relat Disord
January 2025
Division of Rheumatology, Johns Hopkins University, Baltimore, MD, USA.
Autonomic dysfunction is a common and early complication among patients with systemic sclerosis, suggesting that it may play a role in the pathogenesis of the disease and be a potential target for therapeutic interventions. Although the true prevalence of autonomic dysfunction among patients with systemic sclerosis is still unclear, it is estimated that as many as 80% of patients may be affected. Autonomic dysfunction may lead to widespread multi-organ dysfunction through its effects on the cardiovascular system, gastrointestinal tract, urinary tract, sweat and salivary glands, and pupils.
View Article and Find Full Text PDFColor changes in the feet: a sign of autonomic symptoms in systemic sclerosis.
Rheumatology (Oxford)
September 2024
Department of Internal Medicine, The University of Texas Health Science Center at Houston, Division of Rheumatology, Houston, TX, USA.
Objectives: Patients with autonomic dysfunction, or dysautonomia, often report discoloration of their dependent extremities, which is thought to be from venous pooling or acrocyanosis. A subset of patients with systemic sclerosis (SSc) are affected by dysautonomia but may be challenging to identify. We sought to determine whether patients with SSc who report discoloration in their feet have a higher burden of autonomic symptoms, including orthostatic, gastrointestinal (GI), urinary, secretomotor, and pupillomotor.
View Article and Find Full Text PDFTuberculosis is the predominant infection in systemic sclerosis: thirty-year retrospective study of serious infections from a single centre.
Rheumatol Int
November 2024
Unit III, Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India.
To look for the spectrum of infections and the factors predisposing to infection in patients with systemic sclerosis (SSc). In this retrospective study, demographic, clinical features, details of infections, immunosuppressive therapy, and outcomes of patients with SSc attending clinics at department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India from 1990 to 2022 were captured. Multivariable-adjusted logistic regression was applied to identify independent predictors of infection.
View Article and Find Full Text PDFCD40 ligand antagonist dazodalibep in Sjögren's disease: a randomized, double-blinded, placebo-controlled, phase 2 trial.
Nat Med
June 2024
Amgen Inc., Thousand Oaks, CA, USA.
Article Synopsis
- Sjögren's disease (SjD) is an autoimmune disorder without approved therapies, and Dazodalibep (DAZ) is a promising new treatment that targets costimulatory signals in immune cells.
- A clinical trial tested DAZ on two groups of SjD patients: one with moderate-to-severe disease and another with severe symptoms but less organ involvement, measuring changes in disease activity and patient-reported outcomes at day 169.
- Both groups showed significant improvement with DAZ compared to placebo, and the drug was generally safe, though some common adverse events included COVID-19, headaches, and respiratory infections.
Characterization of kidneys in patients with systemic sclerosis by multi-parametric magnetic resonance quantitative imaging.
Magn Reson Imaging
June 2024
Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China. Electronic address:
Article Synopsis
- - The study aimed to assess how effective multiparametric magnetic resonance (MR) imaging is in examining kidneys in patients with systemic sclerosis (SSc) compared to healthy individuals.
- - In 46 patients with SSc and 22 healthy controls, various MR imaging parameters (like T2*, T1 values, renal blood flow) were significantly different between the groups, indicating kidney function issues in SSc patients, particularly those with the diffuse cutaneous form (dcSSc).
- - The findings suggest that multi-delay ASL perfusion imaging can be a valuable tool for better understanding and classifying kidney conditions in SSc patients, as it highlights differences in kidney function that may not be apparent through traditional methods.
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