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Serum vitamin C concentration is influenced by haptoglobin polymorphism and iron status in Chinese.
Clin Chim Acta
March 2006
Department of Chemistry, Beijing Normal University, Beijing 100875, PR China.
Background: Vitamin C is a powerful antioxidant (free radical scavenger). Apart from the diet, other factors regulating its catabolism may affect its serum concentration. Haptoglobin (Hp) is a plasma protein participating in iron metabolism.
View Article and Find Full Text PDFHaptoglobin type neither influences iron accumulation in normal subjects nor predicts clinical presentation in HFE C282Y haemochromatosis: phenotype and genotype analysis.
Br J Haematol
July 2003
Department of Haematology, University of Wales College of Medicine, Cardiff, UK.
In the UK, 90% of patients with hereditary haemochromatosis (HH) are homozygous for HFE C282Y, as are one in 150 people in the general population. However, only a minority of these will develop clinical haemochromatosis. Iron loss modifies iron accumulation but so may other genetic factors.
View Article and Find Full Text PDFHaptoglobin polymorphism, iron metabolism and mortality in HIV infection.
AIDS
June 1998
Department of Clinical Chemistry, Microbiology and Immunology, University Hospital, Gent, Belgium.
Background: Three phenotypes of the antioxidant protein haptoglobin are known: Hp 1-1, Hp 2-1 and Hp 2-2.
Objectives: To investigate the outcome of HIV infection according to haptoglobin type.
Design And Methods: Haptoglobin phenotypes were determined using starch gel electrophoresis in serum obtained from 653 HIV-infected Caucasians in the AIDS reference centers of Gent (n = 184), Antwerp (n = 309), and Luxembourg (n = 160).
Distribution of lymphocyte subsets in bone marrow and peripheral blood is associated with haptoglobin type. Binding of haptoglobin to the B-cell lectin CD22.
Eur J Clin Chem Clin Biochem
March 1997
Central Laboratory, University Hospital Gent, Belgium.
Haptoglobin is an acute phase protein showing a genetic polymorphism with 3 major types: Hp 1-1, Hp 2-1, and Hp 2-2. In this study, flow cytometric analysis demonstrated that all three haptoglobin types bind to CD22 on human B-lymphocytes with equal affinity. Comparison of reference values for lymphocyte subsets in peripheral blood and bone marrow showed significant differences between haptoglobin types.
View Article and Find Full Text PDFDistribution of haptoglobin phenotypes in oesophageal and gastric cancer.
J Med Genet
March 1989
Department of Gastroenterology, Osmania General Hospital, Hyderabad, India.
Haptoglobin (Hp) phenotypes were studied in 72 oesophageal and 104 gastric cancer patients and compared with 100 healthy controls to see if there is any association between oesophageal and gastric cancer and haptoglobin type. There was a significantly increased frequency of Hp 2-1 (59.7%) and Hp 2-2 (91.
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