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Alzheimers Dement
December 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: The burden of Alzheimer's disease and related dementias is growing fast in Africa. The Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the Alzheimer's Disease Sequencing Project (READD-ADSP) has commenced recruitment of 5000 African participants (AD and cognitively unimpaired individuals) to generate genomic and biomarker data to better characterize AD genetic architecture in Africa. Participating countries, part of the African Dementia Consortium (AfDC) include Nigeria, Ghana, Benin, Cameroon, Uganda, Kenya, Ethiopia, Tanzania, and Mozambique.
View Article and Find Full Text PDFBackground: Liquid biopsy for Alzheimer's disease (AD) biomarkers in cerebral spinal fluid (CSF) or blood samples is becoming a significant sector in the management of AD and AD related dementia (ADRD). Whereas different types of molecules, such as small molecules, peptides, and antibodies, have been used as ligands for targeting AD biomarkers/pathologies such as amyloid beta peptides (Aβs), current liquid biopsy approaches mostly use antibodies. However, the activity and affinity of the antibodies can vary depending on the source and preparation as well as the stability in storage.
View Article and Find Full Text PDFDirect Printing of an Electrochemical Device and Its Interface with Paper for Uric Acid Detection in Human Sweat.
ACS Appl Bio Mater
January 2025
Department of Medical Devices, National Institute of Pharmaceutical Education and Research, Guwahati, Assam 781101, India.
Using a laser-scribed (direct printing) technique, we have fabricated an enzymeless, mediatorless, and paper-interfaced electrochemical device (P-LSG) for uric acid detection on a flexible polyimide sheet. Various paper substrates were investigated, and it was found that Whatman filter paper-1 is promising to obtain the best electrochemical signals at the small volume of electrolyte, i.e.
View Article and Find Full Text PDFRole of Mesoporosity in Hard Carbon Anodes for High-Energy and Stable Potassium-Ion Storage.
Small
January 2025
Department of Material Science Engineering, Gachon University, Seongnamdaero 1342, Seongnam, 13120, Republic of Korea.
Herein, NaCl-templated mesoporous hard carbons (NMCs) have been designed and engineered with tunable surface properties as anode materials for potassium-ion batteries (KIBs) and hybrid capacitors (KICs). By utilizing "water-in-oil" emulsions, the size of NaCl templates is precisely modified, leading to smaller particles that enable the formation of primary carbon structures with reduced particle size and secondary structures with 3D interconnected mesoporosity. These features significantly enhance electrode density, reduce particle-to-particle resistance, and improve electrolyte wettability.
View Article and Find Full Text PDFMultifunctional Cyclized Polyacrylonitrile (cPAN) as a Coating for Sb-Based Anodes in Sodium-Ion Batteries.
ACS Appl Mater Interfaces
January 2025
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Conversion electrodes, such as antimony (Sb), are high energy density electrode materials for sodium-ion batteries (NIBs). These materials are limited in their performance due to the mechanical instability of these systems resulting from volume expansion of the material during cycling. Stabilizing conversion materials using a conductive polymer binder (CPB) protective layer is an effective way to enhance the performance of these materials.
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