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Age-Related Changes in Skeletal Muscle of Cattle.
Vet Pathol
March 2016
Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Naples, Italy
Sarcopenia, the age-related loss of muscle mass and strength, is a multifactorial condition that represents a major healthcare concern for the elderly population. Although its morphologic features have been extensively studied in humans, animal models, and domestic and wild animals, only a few reports about spontaneous sarcopenia exist in other long-lived animals. In this work, muscle samples from 60 healthy Podolica-breed old cows (aged 15-23 years) were examined and compared with muscle samples from 10 young cows (3-6 years old).
View Article and Find Full Text PDFMonitoring the effects of treatment in colon cancer cells using immunohistochemical and histoenzymatic techniques.
Rom J Morphol Embryol
November 2016
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Romania;
Background: Monitoring the effects of treatment in malignant diseases is very important in study of the influence on the cell metabolism. Energy production in cancer cells is abnormally dependent on aerobic glycolysis. In addition to the dependency on glycolysis, cancer cells have other atypical metabolic characteristics.
View Article and Find Full Text PDFAge related skeletal muscle atrophy and upregulation of autophagy in dogs.
Vet J
October 2015
Department of Veterinary Medicine and Animal Production, Laboratory of Comparative Neuromuscular Diseases, University of Naples Federico II, via Delpino 1, 80137 Napoli, Italy. Electronic address:
Sarcopenia, the age related loss of muscle mass and strength, is a multifactorial condition that occurs in a variety of species and represents a major healthcare concern for older adults in human medicine. In veterinary medicine, skeletal muscle atrophy is often observed in dogs as they reach old age, but the process is not well understood. Autophagy is a mechanism for degradation and recycling of cellular constituents and is potentially involved in sarcopenia.
View Article and Find Full Text PDFWhole microvascular unit deletions in dermatomyositis.
Ann Rheum Dis
March 2013
Neuropediatry Unit, AP-HP, Necker - Enfants Malades, Hospital, Paris, France.
Objectives: The pathophysiology of dermatomyositis (DM) remains unclear, combining immunopathological mechanisms with ischaemic changes regarded as a consequence of membranolytic attack complex (MAC)-induced capillary destruction. The study is a reappraisal of the microvascular involvement in light of the microvascular organisation in normal human muscle.
Methods: Muscle microvasculature organisation was analysed using 3D reconstructions of serial sections immunostained for CD31, and histoenzymatic detection of endogenous alkaline phosphatase activity of microvessels.
Nicotinamide adenine dinucleotide tetrazolium reductase identifies microvasculature activation in muscle from adult patients with dermatomyositis.
J Rheumatol
January 2012
David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 32-59, Los Angeles, CA 90095-1670, USA.
Objective: Previous work has suggested involvement of the muscle microvasculature in the pathogenesis of dermatomyositis (DM). Our study evaluates whether standard histochemical reactions can identify microvascular changes in muscle biopsies from patients with DM compared to myopathic and nonmyopathic controls.
Methods: Muscle biopsies were obtained from 111 patients, including 45 patients with DM.
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