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Aging and MPTP Sensitivity Depend on Molecular and Ultrastructural Signatures of Astroglia and Microglia in Mice Substantia Nigra.
Cell Mol Neurobiol
January 2025
Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Hosur Road, Bengaluru, 560029, India.
Both astroglia and microglia show region-specific distribution in CNS and often maladapt to age-associated alterations within their niche. Studies on autopsied substantia nigra (SN) of Parkinson's disease (PD) patients and experimental models propose gliosis as a trigger for neuronal loss. Epidemiological studies propose an ethnic bias in PD prevalence, since Caucasians are more susceptible than non-whites.
View Article and Find Full Text PDFEffect of sulfinate salt on bonding and polymerization of adhesive to intracoronally bleached dentin.
Sci Rep
January 2025
Department of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, 34 Henri Dunant Road, Pathumwan, Bangkok, 10330, Thailand.
To evaluate the effect of sulfinate salt on the bond performance of a two-step self-etch adhesive to an intracoronally bleached pulpal dentin surface. Intracoronally bleached bovine teeth were treated with or without sulfinate salt (sulfinate agent (SA): Clearfil DC activator) before 2-SEA (Clearfil SE Bond 2) application, while unbleached teeth served as the control (n = 5 teeth). Microtensile bond strength (µTBS) using the bonded surface area of 1 mm at the crosshead speed of 1 mm/min measurements after 24 h storage and thermocycles (TC), degree of conversion (DC) analyses by Raman spectroscopy (n = 3 teeth), ultrastructure of resin-dentin interface (n = 3 teeth), and intracoronally bleached pulp chamber dentin surface (n = 3 teeth) observations by scanning electron microscopy (SEM) were subsequently performed.
View Article and Find Full Text PDFGold Nanoparticles and Induction of Structural Alteration and Enhanced Oxidative Stress in Rat Lens.
Food Chem Toxicol
January 2025
Department of Histology, Kasr Al-ainy Faculty of Medicine, Cairo University, Egypt. Electronic address:
There is an emerging wide use of nanotechnology in the medical fields. The information regarding distribution and clearance of gold nanoparticles (AuNPs) in the ocular tissue is insufficient. We investigated the cumulative effect of AuNPs on rat lens structure and their effect on the redox state and aquaporin-0 (AQP0) expression.
View Article and Find Full Text PDFS1PR3 in hippocampal neurons improves synaptic plasticity and decreases depressive behavior via downregulation of RhoA/ROCK1.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:
The study investigates how Sphingosine-1-phosphate receptor 3 (S1PR3) and the Chronic Unpredictable Mild Stress (CUMS) affects depression-like behaviors. The S1P/S1PR3 signaling pathway is known to play a role in mood regulation, but it is not yet fully understood how it is connected to depression. This study looks to further explore this topic.
View Article and Find Full Text PDFLycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice.
Exp Gerontol
January 2025
Department of Microbiology and Immunology, School of Medicine; Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou 510632, China; Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632, China; Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, School of Medicine, Jinan University, Guangzhou 510632, China; Zhuhai Institute of Jinan University, Zhuhai 519070, China. Electronic address:
Background: Aging is a complex biological process that disrupts tissue structure and impairs physiological function, which contributes to the development of age-related diseases such as cardiovascular disorders. However, effective treatment strategies are lacking.
Objective: To investigate the geroprotective effects of Lycium barbarum glycopeptide (LbGp) and its potential mechanisms in a D-galactose-induced accelerated aging mouse model.
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