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Qualitative Comparison of Cultured Skin Microbiota From the Inguinal Region of Obese and Nonobese Patients Eligible for Hip Arthroplasty.
Arthroplast Today
December 2024
Institute for Hygiene and Microbiology, University of Wuerzburg, Würzburg, Germany.
Background: With the rising prevalence of obesity, surgeons are frequently confronted with the problem of treating osteoarthritis of the hip via arthroplasty (total hip arthroplasty) in severely obese patients. To reduce the surgical impact, minimal-invasive approaches are often chosen. For this reason, the direct anterior approach has gained popularity but is suspected of leading to more wound complications in obese patients, especially by Gram-negative pathogens.
View Article and Find Full Text PDF (Rutaceae), a new tree species from Kaua'i, Hawaiian Islands.
PhytoKeys
December 2024
National Museum of Natural History, Smithsonian Institution, PO Box 37012, Washington, DC 20013-7012, USA National Museum of Natural History, Smithsonian Institution Washington United States of America.
A newly-discovered endemic tree species of from Kaua'i, Hawaiian Islands, is described and illustrated with notes on its distribution, ecology, conservation status and phylogenetic placement. A modification to the existing key to Hawaiian is also provided. is a member of Stone's group having carpels connate at base, capsules 4-lobed and leaves usually opposite.
View Article and Find Full Text PDFImpact of mesenchymal stem cell size and adhesion modulation on in vivo distribution: insights from quantitative PET imaging.
Stem Cell Res Ther
November 2024
Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, P.R. China.
Article Synopsis
- The study investigates how biophysical factors, specifically cell size and adhesion capacity, affect the distribution and effectiveness of mesenchymal stem cells (MSCs) for tissue repair.
- Researchers utilized surface modification techniques and a hanging drop method to alter the size and adhesion of MSCs, then tracked their biodistribution in living rodents using PET imaging.
- Results indicate that while adhesion capacity modifications didn't significantly impact lung entrapment, reducing MSC size enhanced their ability to migrate to other organs, highlighting that cell size is a key factor in MSC localization.
A bioswitchable delivery system for microRNA therapeutics based on a tetrahedral DNA nanostructure.
Nat Protoc
February 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P. R. China.
As microRNAs (miRNA) regulate almost all physiopathological activities in the human body, miRNA therapeutics that deliver miRNA regulators have attracted considerable attention in the field of nucleic acid drug development. The use of tetrahedral DNA nanostructures to deliver miRNA regulators is promising because of their simple fabrication, enhanced cell entry, effective tissue penetration, biocompatibility and functional editability. This protocol extension builds on our previous protocol for the use of tetrahedral DNA nanostructures and was designed to establish an updated bioswitchable delivery system (BDS) for achieving controlled cargo loading and release.
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