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Analyzing gene-based apoptotic biomarkers in insomnia using bioinformatics.
Medicine (Baltimore)
January 2025
Geriatric Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Insomnia is increasingly common and poses significant health risks. The aims of this study are to identify apoptosis-related genes and potential biomarkers for insomnia and to find new therapeutic targets. Insomnia gene expression profiles were downloaded from the Gene Expression Omnibus database, and differentially expressed genes in normal and insomnia samples were identified by limma rapid differential analysis, and then the major modular genes with clinical relevance to insomnia were analyzed using the Weighted Gene Co-Expression Network Analysis, and intersections were obtained with the differentially expressed genes as well as with apoptotic gene databases.
View Article and Find Full Text PDFSensitivity of Functional Arterial Spin Labelling in Detecting Cerebral Blood Flow Changes.
Br J Hosp Med (Lond)
December 2024
Department of Neurology, Wuhan Brain Hospital, General Hospital of Yangtze River Shipping, Wuhan, Hubei, China.
Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) method. ASL techniques can quantitatively measure cerebral perfusion by fitting a kinetic model to the difference between labelled images (tag images) and ones which are acquired without labelling (control images). ASL functional MRI (fMRI) provides quantitative perfusion maps by using arterial water as an endogenous tracer instead of depending on vascular blood oxygenation level.
View Article and Find Full Text PDFSize and Topography of the Brain's Functional Networks with Psychotic Experiences, Schizophrenia, and Bipolar Disorder.
Biol Psychiatry Glob Open Sci
November 2024
Department of Psychiatry, Washington University Medical School, St Louis, Missouri.
Background: Existing functional connectivity studies of psychosis use population-averaged functional network maps, despite highly variable topographies of these networks across the brain surface. We aimed to define the functional network areas and topographies in the general population and the changes associated with psychotic experiences (PEs) and disorders.
Methods: Maps of 8 functional networks were generated using an individual-specific template-matching procedure for each participant from the Human Connectome Project Young Adult cohort ( = 1003) and from a matched case cohort (schizophrenia [SCZ], = 27; bipolar disorder, = 35) scanned identically with the same Connectom scanner.
Computational theories posit that attention is guided by a combination of spatial maps for individual features that can be dynamically weighted according to task goals. Consistent with this framework, when a stimulus contains several features, attending to one or another feature results in stronger fMRI responses in regions preferring the attended feature. We hypothesized that multivariate activation patterns across feature-responsive cortical regions form spatial 'feature dimension maps', which combine to guide attentional priority.
View Article and Find Full Text PDFUnlabelled: Adaptive behavior in complex environments requires integrating visual perception with memory of our spatial environment. Recent work has implicated three brain areas in posterior cerebral cortex - the place memory areas (PMAs) that are anterior to the three visual scene perception areas (SPAs) - in this function. However, PMAs' relationship to the broader cortical hierarchy remains unclear due to limited group-level characterization.
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