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Brivaracetam to Treat Partial Onset Seizures in Adults.
Health Psychol Res
January 2023
University of Central Florida College of Medicine, Orlando, FL and HCA Osceola Hospital, Kissimmee, FL.
Purpose Of Review: Seizures are a hyperexcitable, and hypersynchronous imbalance between excitatory and inhibitory factors (E/I imbalance) in neurotransmission, and epilepsy is the recurrent manifestation of seizures within a reasonable time frame and without being attributable to a reversible cause. Brivaracetam is a derivative of the antiepileptic agent, levetiracetam, that is used as adjuvant therapy for focal onset seizures. It was approved by the FDA in 2016 and has shown promising results with minimal adverse effect reactions in clinical trials.
View Article and Find Full Text PDFThe Relationship Between the Rhythmic Components of the Brain Electrical Activity During the Development of Status Epilepticus: An Operational Model of Brain Rhythms Generation.
Brain Connect
August 2022
Laboratory of Systemic organization of Neurons, Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, Pushchino, Russian Federation.
Despite the fact that brain rhythms are widely studied and officially classified, there is no consensus on their relationship, which can shed light on the genesis of rhythmic activity, its synchronization, functional role, and the formation of pathological reactions. Using the experimental status epilepticus (SE) as a model of brain in a hypersynchronized state with well-defined rhythms, we aimed to study the relationship between the rhythmic components of the brain electrical activity. Local field potentials (LFPs) were recorded simultaneously from the hippocampus, entorhinal cortex, medial septum, and amygdala during normal conditions and after kainic acid (KA) administration in waking guinea pigs.
View Article and Find Full Text PDFSeizure onset predicts its type.
Epilepsia
March 2018
Epilepsy Center, University Hospital of Freiburg, Freiburg, Germany.
Objective: Epilepsy is characterized by transient alterations in brain synchronization resulting in seizures with a wide spectrum of manifestations. Seizure severity and risks for patients depend on the evolution and spread of the hypersynchronous discharges. With standard visual inspection and pattern classification, this evolution could not be predicted early on.
View Article and Find Full Text PDFDisinhibition of the intergeniculate leaflet network in the WAG/Rij rat model of absence epilepsy.
Exp Neurol
March 2017
Department of Neurophysiology and Chronobiology, Institute of Zoology, Jagiellonian University in Krakow, Krakow, Poland. Electronic address:
The intergeniculate leaflet (IGL) of the thalamus is a retinorecipient structure implicated in orchestrating circadian rhythmicity. The IGL network is highly GABAergic and consists mainly of neuropeptide Y-synthesising and enkephalinergic neurons. A high density of GFAP-immunoreactive astrocytes has been observed in the IGL, with a probable function in guarding neuronal inhibition.
View Article and Find Full Text PDFComplex Rotating Waves and Long Transients in a Ring Network of Electrochemical Oscillators with Sparse Random Cross-Connections.
Phys Rev Lett
February 2016
Department of Chemistry, Saint Louis University, 3501 Laclede Avenue, St. Louis, Missouri 63103, USA.
We perform experiments and phase model simulations with a ring network of oscillatory electrochemical reactions to explore the effect of random connections and nonisochronicity of the interactions on the pattern formation. A few additional links facilitate the emergence of the fully synchronized state. With larger nonisochronicity, complex rotating waves or persistent irregular phase dynamics can derail the convergence to global synchronization.
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