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Defining Substantial Clinical Benefits of PROMIS Pain Interference and Physical Function in Patients Undergoing Lumbar and Thoracolumbar Spine Surgery.
Spine (Phila Pa 1976)
January 2025
Department of Neurological Surgery, Washington University, St. Louis, MO, USA.
Study Design: Prospective cohort study.
Objective: This study aims to define Substantial Clinical Benefit (SCB) thresholds for PROMIS physical function (PF) and pain interference (PI) in lumbar or thoracolumbar spine surgery population.
Summary Of Background Data: Patient-reported outcome measures (PROMs) are widely used in spine surgery to assess treatment efficacy.
Spinal schistosomiasis masquerading as spinal cord tumor in a 12-year-old male adolescent: A case report.
Radiol Case Rep
March 2025
School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Spinal schistosomiasis, a rare manifestation of schistosomal infection, can closely mimic the presentation of spinal cord tumors and pose significant diagnostic challenges. We present the case of a 12-year-old boy from northern Ethiopia who experienced progressive back pain, tingling sensations in his lower extremities, and intermittent fever. Initially referred with a presumptive diagnosis of myxopapillary ependymoma for pediatric hematology-oncology evaluation, his marked eosinophilia and history of swimming in local rivers raised suspicion for spinal schistosomiasis.
View Article and Find Full Text PDFA previously healthy 30-year-old woman experienced worsening back pain, fatigue, weakness, loss of appetite, and facial puffiness. After 18 months of these symptoms, she was diagnosed with multiple myeloma, which was also damaging her kidneys. The treatment involved a combination of medications and blood transfusions, leading to improved kidney function.
View Article and Find Full Text PDFEvaluating Tech Neck: A Pilot Study Using a Self-Developed Questionnaire on Symptoms, Posture, and Preventive Measures.
Children (Basel)
January 2025
Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Background/objectives: Musculoskeletal symptoms, such as neck pain, back pain, and eye strain, are prevalent in modern work environments, particularly among individuals engaged in prolonged sitting and repetitive tasks. This study aimed to explore the prevalence of these symptoms and the impact of ergonomic tool usage, break frequency, posture awareness, and proactive measures on symptom intensity and daily functioning.
Methods: This cross-sectional pilot study used a self-developed questionnaire to assess the prevalence and intensity of musculoskeletal symptoms among participants aged 6-18 years.
Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2/PINK1 pathway.
Acta Biochim Biophys Sin (Shanghai)
January 2025
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP), and effective therapies are still lacking. Reactive oxygen species (ROS) stress induces NLRP3 inflammasome activation, and this, along with extracellular matrix metabolism (ECM) degradation in nucleus pulposus cells (NPCs), plays a crucial role in the progression of IDD. Daphnetin (DAP) is a biologically active phytochemical extracted from plants of the , which possesses various bioactivities, including antioxidant properties.
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