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BACKGROUND Herpes simplex virus (HSV) is a rare cause of hepatitis. HSV hepatitis can be life-threatening due to its rapid progression to liver failure if not treated on time. It affects primarily immunocompromised individuals but can also present in immunocompetent hosts.

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Article Synopsis
  • Acute hepatitis A commonly affects children in developing countries, often presenting without symptoms, but can occasionally lead to rare complications beyond the liver.
  • An 8-year-old child presented with abdominal pain, jaundice, and abdominal distension, ultimately diagnosed with acute hepatitis A along with pleural effusion, acalculous cholecystitis, and ascites.
  • This case highlights the rarity of concurrent extrahepatic manifestations of hepatitis A in children, emphasizing the need for pediatricians to recognize and manage such cases to prevent unnecessary tests.
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Leptospirosis is a zoonotic infection primarily caused by bacteria of the genus This infectious disease mainly occurs through direct contact with infected animals or indirect contact via contaminated soil or water. While the incidence rate of leptospirosis in the developing world is as high as 100 cases per 100,000 population, the incidence rate in the United Kingdom is low (0.14 cases per 100,000 population).

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Abnormalities of liver function in giant cell arteritis (GCA) have long been described and are present at the acute phase of the disease in 30% to 60% of cases. Hepatic involvement is mostly anicteric cholestasis (eg, elevated alkaline phosphatase [ALP] and gamma-glutamyl transferase [GGT]), and, more rarely, cytolytic hepatitis (eg, elevated aspartate aminotransferase [AST] and/or alanine aminotransferase [ALT]).

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