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Crown Gall Induced by a Natural Isolate of () Containing a Tumor-Inducing Plasmid.
Microorganisms
January 2025
Institute Biology Leiden (IBL), Leiden University, 2333 BE Leiden, The Netherlands.
Crown gall disease in plants is caused by "Agrobacteria", bacteria belonging to the family, which carry a tumor-inducing (Ti) plasmid. Unexpectedly, we found evidence that a natural isolate from a rose crown gall, called NBC51/LBA8980, was a bacterium that did not belong to the family. Whole-genome sequencing revealed that this bacterium contained three large DNA circles with rRNA and tRNA genes, representing one chromosome and two chromids, respectively, and two megaplasmids, including a Ti plasmid.
View Article and Find Full Text PDFMultienzyme-like polyoxometalate for oxygen-independent sonocatalytic enhanced cancer therapy.
J Colloid Interface Sci
March 2025
School of Materials and Chemistry, Institute of Bismuth Science, University of Shanghai for Science and Technology, Shanghai 200093, China; Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, Shanghai 200093, China. Electronic address:
Artificially synthesized nanozymes exhibit enzymatic activity similar to that of natural enzymes. However, in the complex tumor microenvironment, their diversity and catalytic activity show significant variations, limiting their effectiveness in catalytic therapy. Developing artificial enzymes with multiple enzymatic activities and spatiotemporal controllable catalytic abilities is of great clinical significance.
View Article and Find Full Text PDFPositive-strand RNA virus genome replication organelles: structure, assembly, control.
Trends Genet
August 2024
Rowe Center for Virology, Morgridge Institute for Research, Madison, WI, USA; Institute for Molecular Virology, University of Wisconsin-Madison, Madison, WI; McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI. Electronic address:
Positive-strand RNA [(+)RNA] viruses include pandemic SARS-CoV-2, tumor-inducing hepatitis C virus, debilitating chikungunya virus (CHIKV), lethal encephalitis viruses, and many other major pathogens. (+)RNA viruses replicate their RNA genomes in virus-induced replication organelles (ROs) that also evolve new viral species and variants by recombination and mutation and are crucial virus control targets. Recent cryo-electron microscopy (cryo-EM) reveals that viral RNA replication proteins form striking ringed 'crowns' at RO vesicle junctions with the cytosol.
View Article and Find Full Text PDFSignificance of PSCA as a novel prognostic marker and therapeutic target for cancer.
Cancer Cell Int
April 2024
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
One of the contributing factors in the diagnosis and treatment of most cancers is the identification of their surface antigens. Cancer tissues or cells have their specific antigens. Some antigens that are present in many cancers elicit different functions.
View Article and Find Full Text PDFAnticancer Effects of Rosmarinus officinalis Leaf Extract on KB Cell Lines.
Cureus
February 2024
Centre of Molecular Medicine and Diagnostics (COMManD) Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha University, Chennai, IND.
Background The value and use of medicinal plants, including the widespread cultivation of , have increased rapidly. , a medicinal plant native to the Mediterranean, has received attention for its potential therapeutic benefits. This study evaluates anticancer activity using human epithelial carcinoma (KB) cell lines derived from nasopharyngeal epidermoid carcinoma.
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