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A new epidemic model of sexually transmittable diseases: a fractional numerical approach.
Sci Rep
January 2025
Department of Mathematics, College of Science Al-Zulfi, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
This study aims at investigating the dynamics of sexually transmitted infectious disease (STID), which is serious health concern. In so doing, the integer order STID model is progressed in to the time-delayed non-integer order STID model by introducing the Caputo fractional derivatives in place of integer order derivatives and including the delay factors in the susceptible and infectious compartments. Moreover, unique existence of the solution for the underlying model is ensured by establishing some benchmark results.
View Article and Find Full Text PDFDetection and correction of translational motion in SPECT with exponential data consistency conditions.
Phys Med Biol
January 2025
Université de Lyon, CREATIS ; CNRS UMR5220 ; Inserm U1206 ; INSA-Lyon ; Université Lyon 1, CREATIS, Centre Léon Bérard, Lyon, 69373, FRANCE.
Rigid patient motion can cause artifacts in single photon emission computed tomography (SPECT) images, compromising the diagnosis and treatment planning. Exponential data consistency conditions (eDCCs) are mathematical equations describing the redundancy of exponential SPECT measurements. It has been recently shown that eDCCs can be used to detect patient motion in SPECT projections.
View Article and Find Full Text PDFUnravelling the aromatic symphony: redirecting bifunctional mushroom synthases towards linalool monofunctionality.
Adv Biotechnol (Singap)
January 2025
Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore, Republic of Singapore.
Enzymes are the cornerstone of biocatalysis, biosynthesis and synthetic biology. However, their applicability is often limited by low substrate selectivity. A prime example is the bifunctional linalool/nerolidol synthase (LNS) that can use both geranyl diphosphate (GPP) and farnesyl diphosphate (FPP) to produce linalool and nerolidol, respectively.
View Article and Find Full Text PDFAn Intrathecal Pump Misadventure in Two Acts: An Unrecognized Partial Pocket Fill Followed by an Unusual Withdrawal Syndrome Two Months Later.
J Palliat Med
January 2025
Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
We present a case of a patient with an intrathecal pump who experienced an unrecognized partial pocket fill, leading to an atypical opioid withdrawal characterized by akathisia. A 57-year-old female with multiple myeloma presented to an emergency department with new-onset akathisia requiring admission. Eight weeks prior, her intrathecal pump was refilled with morphine, bupivacaine, and ziconotide.
View Article and Find Full Text PDFUsing Machine Learning to Design a FeMOF Bidirectional Regulator for Electrochemiluminescence Sensing of Tau Protein.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of the Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
The single-luminophore-based ratiometric electrochemiluminescence (ECL) sensor coupling bidirectional regulator has become a research hotspot in the detection field because of its simplicity and accuracy. However, the limited bidirectional regulator hinders its further development. In this study, by leveraging the robust predictive capabilities of machine learning, we prepared an Fe-based metal-organic framework (FeMOF) as a bidirectional regulator for modulating the dual-emission ECL signals of a single luminophore for the first time.
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