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Improving rupture status prediction for intracranial aneurysms using wall shear stress informatics.
Acta Neurochir (Wien)
January 2025
Department of Neurosurgery, College of Medicine, University of Michigan, Ann Arbor, MI, USA.
Background: Wall shear stress (WSS) plays a crucial role in the natural history of intracranial aneurysms (IA). However, spatial variations among WSS have rarely been utilized to correlate with IAs' natural history. This study aims to establish the feasibility of using spatial patterns of WSS data to predict IAs' rupture status (i.
View Article and Find Full Text PDFLate-onset Systemic Lupus Erythematosus.
Rheumatol Int
January 2025
Department of Rheumatology, Immunology and Internal Medicine, University Hospital in Kraków, Kraków, Poland.
Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) that results from the dysregulation of multiple innate and adaptive immune pathways. Late-onset SLE (Lo-SLE) is the term used when the disease is first diagnosed after 50-65 years, though the standard age cut-off remains undefined. Defining "late-onset" as lupus with onset after 50 years is more biologically plausible as this roughly corresponds to the age of menopause.
View Article and Find Full Text PDFLong-Term Natural History of Autoimmune Gastritis: Results From a Prospective, Monocentric Series.
Am J Gastroenterol
January 2025
Department of Gastroenterology and Hepatology, Xuanwu Hospital, Capital Medical University, Beijing, China.
The Relationship between Body Mass Index and Level of Response to Alcohol Across the Spectrum of Alcohol Use: Total Body Water and Beyond.
J Stud Alcohol Drugs
January 2025
Human Psychopharmacology Laboratory, Division of Intramural Clinical and Biological Research (DICBR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland, USA.
Background: A low level of response (LR) to alcohol is a known risk factor for alcohol use disorder (AUD). Although higher total body water (TBW) is associated with lower blood alcohol concentrations and reduced responses following alcohol consumption, the relationship between morphometric measures such as body mass index (BMI) and LR is less clear. This study aimed to examine the relationship between BMI and LR to alcohol, and the contribution of TBW to this relationship.
View Article and Find Full Text PDFRapid Parallel Adaptation in Distinct Invasions of Ambrosia Artemisiifolia Is Driven by Large-Effect Structural Variants.
Mol Biol Evol
January 2025
School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.
When introduced to multiple distinct ranges, invasive species provide a compelling natural experiment for understanding the repeatability of adaptation. Ambrosia artemisiifolia is an invasive, noxious weed, and chief cause of hay fever. Leveraging over 400 whole-genome sequences spanning the native-range in North America and 2 invasions in Europe and Australia, we inferred demographically distinct invasion histories on each continent.
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