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Streptolysin O accelerates the conversion of plasminogen to plasmin.
Nat Commun
November 2024
Division of Infection Medicine, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host. In this study, we use affinity-enrichment mass spectrometry to decipher the host-pathogen protein-protein interaction between plasminogen and streptolysin O, a key cytolytic toxin produced by GAS. This interaction accelerates the conversion of plasminogen to plasmin by both the host tissue-type plasminogen activator and streptokinase, a bacterial plasminogen activator secreted by GAS.
View Article and Find Full Text PDFFibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications.
Semin Thromb Hemost
July 2024
Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Article Synopsis
- * Urokinase and tissue plasminogen activator (tPA) were later discovered, with tPA being cloned and developed into various derivatives like alteplase, tenecteplase, and reteplase to improve effectiveness.
- * Alteplase is FDA-approved for conditions such as pulmonary embolism, STEMI, and acute ischemic stroke, while reteplase and tenecteplase are also approved for STEMI treatment; the review highlights their
Chemical Adjustment of Fibrinolysis.
Pharmaceuticals (Basel)
January 2024
Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 109029 Moscow, Russia.
Fibrinolysis is the process of the fibrin-platelet clot dissolution initiated after bleeding has been stopped. It is regulated by a cascade of proteolytic enzymes with plasmin at its core. In pathological cases, the balance of normal clot formation and dissolution is replaced by a too rapid lysis, leading to bleeding, or an insufficient one, leading to an increased thrombotic risk.
View Article and Find Full Text PDFPlasminogen activation and plasmin inhibition during in vitro fertilization in bovine: implications for fertilization parameters and early embryo development.
Reprod Biol
March 2024
Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, and Instituto de Biología 'Dr. Francisco D. Barbieri', Facultad de Bioquímica, Química y Farmacia, UNT, Chacabuco 461 (4000), San Miguel de Tucumán, Tucumán, Argentina. Electronic address:
Components of the plasminogen/plasmin system, known to be present in the oocyte, play a key role in maturation and fertilization. The objective of this study was to examine the effect of plasminogen activation and plasmin inhibition by exogenous supplementation of the IVF medium with streptokinase (SK) or ɛ-aminocaproic acid (ε-ACA), respectively, on fertilization parameters and preimplantation embryo development. After in vitro maturation, bovine cumulus-oocyte complexes (COCs) were inseminated in the presence of SK or ε-ACA.
View Article and Find Full Text PDFFibrin and Fibrinolytic Enzyme Cascade in Thrombosis: Unravelling the Role.
Life (Basel)
November 2023
Biological Faculty of Lomonosov, Moscow State University, 119234 Moscow, Russia.
Blood clot formation in blood vessels (thrombosis) is a major cause of life-threatening cardiovascular diseases. These clots are formed by αA-, βB-, and ϒ-peptide chains of fibrinogen joined together by isopeptide bonds with the help of blood coagulation factor XIIIa. These clot structures are altered by various factors such as thrombin, platelets, transglutaminase, DNA, histones, and red blood cells.
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