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Merkel cell: Friend or felon.
J Oral Maxillofac Pathol
October 2024
Department of Oral Pathology and Microbiology, ITS-CDSR, Muradnagar, Ghaziabad, Uttar Pradesh, India.
Merkel cells are perceived as tactile receptors within skin and oral mucosa containing abundant intermediate filaments but lacking characteristic condensation of tonofilaments, hence are also referred to as non-keratinocytes. Merkel cell carcinomas (MCCs) are primary aggressive neuroendocrine neoplasms occurring in elderly individuals. Toker in 1972 reported MCC of skin pointing towards sweat glands as the source of origin which was later rectified by Tang with the aid of ultrastructural studies as Merkel cells to be a lineage of such tumours.
View Article and Find Full Text PDFCHANGES IN THE ULTRASTRUCTURAL ELEMENTS OF PERIODONTAL NEUROTROPHY UNDER CONDITIONS OF ACUTE SIMPLE COAGULATION DYSTROPHY IN THE EXPERIMENT.
Pol Merkur Lekarski
January 2024
UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Objective: Aim: To determine the role of damage to the ultrastructural elements of the periodontal nervous system in the pathogenesis of dystrophic periodontal disease.
Patients And Methods: Materials and Methods: The basis of the experimental part of the study was the preparation of ultrathin sections from blocks of gum tissue of white rats, which were prepared using the UMTP-3M device. The study and analysis of biopsy samples was carried out with the help of an electron microscope UEMV-100K.
Cellular composition modifies the biological properties and stability of platelet rich plasma membranes for tissue engineering.
J Biomed Mater Res A
November 2023
Regenerative Medicine Laboratory, BTI-Biotechnology Institute, Vitoria, Spain.
Scaffolds should provide structural support for tissue regeneration, allowing their gradual biodegradation and interacting with cells and bioactive molecules to promote remodeling. Thus, the scaffold's intrinsic properties affect cellular processes involved in tissue regeneration, including migration, proliferation, differentiation, and protein synthesis. In this sense, due to its biological effect and clinical potential, Platelet Rich Plasma (PRP) fibrin could be considered a successful scaffold.
View Article and Find Full Text PDFNovel ITGB6 variants cause hypoplastic-hypomineralized amelogenesis imperfecta and taurodontism: characterization of tooth phenotype and review of literature.
BDJ Open
April 2023
Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Objectives: To characterize phenotype and genotype of amelogenesis imperfecta (AI) in a Thai patient, and review of literature.
Materials And Methods: Variants were identified using trio-exome and Sanger sequencing. The ITGB6 protein level in patient's gingival cells was measured.
Ultrastructural Characterization of Human Gingival Fibroblasts in 3D Culture.
Cells
November 2022
Department of Integrated Basic Studies, Faculty of Dentistry, Universidad de Antioquia, Medellín 050010, Colombia.
Cell spheroids are applied in various fields of research, such as the fabrication of three-dimensional artificial tissues in vitro, disease modeling, stem cell research, regenerative therapy, and biotechnology. A preclinical 3D culture model of primary human gingival fibroblasts free of external factors and/or chemical inducers is presented herein. The ultrastructure of the spheroids was characterized to establish a cellular model for the study of periodontal tissue regeneration.
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