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Inherited non-syndromic polydactyly in a Berber and Arabian-Berber horse family.
Equine Vet J
January 2025
Université de Lyon, VetAgro Sup, Marcy l'Etoile, France.
Background: Supernumerary digits, or polydactyly, have been described in various species including humans, wild and domestic animals. In horses, it represents the most common congenital limb malformation, which has only been described in isolated cases or nuclear families. Molecular aetiology has not been reported.
View Article and Find Full Text PDFRealistic total-body J-PET geometry optimization: Monte Carlo study.
Med Phys
January 2025
Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland.
Background: Total-body (TB) Positron Emission Tomography (PET) is one of the most promising medical diagnostics modalities, opening new perspectives for personalized medicine, low-dose imaging, multi-organ dynamic imaging or kinetic modeling. The high sensitivity provided by total-body technology can be advantageous for novel tomography methods like positronium imaging, demanding the registration of triple coincidences. Currently, state-of-the-art PET scanners use inorganic scintillators.
View Article and Find Full Text PDFThe qualitative analysis of trabecular architecture of the proximal femur based on the P45 sectional plastination technique.
J Anat
January 2025
Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
The primary weight-bearing structure of the proximal femur, trabecular bone, has a complex three-dimensional architecture that was previously difficult to comprehensively display. This study examined the spatial architecture of trabecular struts in the coronal, sagittal, and horizontal sections of the proximal femur using 21 cases prepared with P45 sectional plasticization. The primary compressive strut (PCS) exhibited a "mushroom-like" shape with upper and lower parts.
View Article and Find Full Text PDFMetagenomic and Transcriptomic Analysis Reveals Crosstalk Between Intratumor Mycobiome and Hosts in Early-Stage Nonsmoking Lung Adenocarcinoma Patients.
Thorac Cancer
January 2025
Department of Thoracic Surgery and Lung Transplantation, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Background: The mycobiome in the tumor microenvironment of non-smokers with early-stage lung adenocarcinoma (ES-LUAD) has been minimally investigated.
Methods: In this study, we conducted ultra-deep metagenomic and transcriptomic sequencing on 128 samples collected from 46 nonsmoking ES-LUAD patients and 41 healthy controls (HC), aiming to characterize the tumor-resident mycobiome and its interactions with the host.
Results: The results revealed that ES-LUAD patients exhibited fungal dysbiosis characterized by reduced species diversity and significant imbalances in specific fungal abundances.
Prognostic Implications of Decorin, E-Cadherin and EGFR Expression in Inflammatory and Non-Inflammatory Canine Mammary Carcinomas.
Vet Comp Oncol
January 2025
Laboratory of Comparative and Translational Oncology, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga, São Paulo, Brazil.
Inflammatory mammary carcinoma (IMC) is the most aggressive variant of invasive mammary tumours in dogs and in women. Decorin is an extracellular matrix molecule whose expression can be reduced or absent in various human cancers, which is associated with a poor prognosis. E-cadherin is a cell adhesion protein whose expression is reduced in several neoplasms.
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