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The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes.
Front Bioeng Biotechnol
January 2025
Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany.
This study investigates the mechanical properties as well as and cyto- and biocompatibility of collagen membranes cross-linked with glutaraldehyde (GA), proanthocyanidins (PC), hexamethylendiisocyanate (HMDI) and 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EC/NHS). A non-crosslinked membrane was used as reference control (RF). The initial cytotoxic analyses revealed that the PC, EC, and HMDI crosslinked membranes were cytocompatible, while the GA crosslinked membrane was cytotoxic and thus selected as positive control in the further study.
View Article and Find Full Text PDFNew insight into the protective effect of Citrullus colocynthis loaded with ZnONP cream on glutaraldehyde-induced dermatitis in health care workers.
Sci Rep
January 2025
Biochemistry Department, Faculty of Agriculture, Al Azhar University, Cairo, Egypt.
Glutaraldehyde (GLU) is mainly used in medicine by healthcare workers during infection control as a chemical disinfectant. It has been linked to numerous health hazards that range from asthma to irritation of the eye to contact dermatitis. Citrullus colocynthis (C.
View Article and Find Full Text PDFSpatiotemporal Retention of Structural Color and Induced Stiffening in Crosslinked Hydroxypropyl Cellulose Beads.
Macromol Rapid Commun
December 2024
Department of Fibre and Polymer Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, SE-100 44, Sweden.
Hydroxypropyl cellulose (HPC) is known for its ability to form cholesteric liquid crystalline phases displaying vivid structural colors. However, these vibrant colors tend to fade over time when the material dries. This issue is a major bottleneck to finding practical applications for these materials.
View Article and Find Full Text PDFCollagen crosslinking-induced corneal morphological changes: a three-dimensional light sheet Microscopy-based evaluation.
Sci Rep
November 2024
Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, Goettingen, 37075, Germany.
Stiffness-related eye diseases such as keratoconus require comprehensive visualization of the complex morphological matrix changes. The aim of this study was to use three-dimensional (3D) light sheet fluorescence microscopy (LSFM) to analyze unlabeled corneal tissue samples, qualitatively visualizing changes in corneal stiffness. Isolated porcine corneal tissue samples were treated with either NaCl or 0.
View Article and Find Full Text PDFRole of crosslinkers in advancing chitosan-based biocomposite scaffolds for bone tissue engineering: A comprehensive review.
Int J Biol Macromol
December 2024
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India. Electronic address:
Bone tissue engineering (BTE) aims to repair and regenerate damaged bone tissue by combining cells, scaffolds, and signaling molecules. Various macromolecules, including natural polymers like chitosan (CS), collagen, hyaluronic acid, and alginate, as well as synthetic polymers such as polyethylene glycol and polylactic acid, are used in scaffold fabrication. Among these, CS holds significant potential in BTE due to its biocompatibility, biodegradability, and other features.
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