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The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure.
Nat Commun
January 2025
University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly reduces CBG binding affinity, potentially increasing 'free' glucocorticoid levels at sites of inflammation. NE is inhibited by alpha-1-antitrypsin (AAT; SERPINA1).
View Article and Find Full Text PDFRegulation and function of the gill corticotropin-releasing factor system during osmoregulatory disturbances in Atlantic salmon.
J Exp Biol
January 2025
Department of Integrative Biology, University of Guelph, 50 Stone Road East, Guelph, ON, Canada, N1G 2W1.
While corticosteroids, including cortisol, have conserved osmoregulatory functions, the relative involvement of other stress-related hormones in osmoregulatory processes remains unclear. To address this gap, we initially characterized the gill corticotropin-releasing factor (CRF) system of Atlantic salmon (Salmo salar) and then determined: (1) how it is influenced by osmotic disturbances; (2) whether it is affected by cortisol; and (3) which physiological processes it regulates in the gills. Most CRF system components were expressed in the gills, with CRF receptor 2 (crfr2a), CRF binding protein (crfbp1 and crfbp2) and urocortin 2 (ucn2a) being the most abundant.
View Article and Find Full Text PDFThe Impact of Maternal Gestational Diabetes Mellitus on Minipuberty in Boys.
Nutrients
November 2024
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland.
Background/objectives: Minipuberty is thought to play an important role in the sexual maturation of infants. Maternal disorders during pregnancy were found to have an impact on the activity of the reproductive axis in the first year of life. This prospective, matched, cohort study was aimed at investigating whether the course of minipuberty in boys is affected by maternal gestational diabetes mellitus (GDM).
View Article and Find Full Text PDFClinical Trial: Safety and Efficacy of a Novel Oesophageal Delivery System for Topical Corticosteroids Versus Placebo in the Treatment of Eosinophilic Oesophagitis.
Aliment Pharmacol Ther
February 2025
Department of Medicine, Division of Gastroenterology and Hepatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, USA.
Background: EsoCap is a thin mucoadhesive film designed to target the oesophageal mucosa. The device loaded with mometasone furoate (ESO-101) is under investigation for the treatment of eosinophilic oesophagitis (EoE).
Aims: To evaluate the efficacy, safety and tolerability of ESO-101 in patients with active EoE.
The effects of power posing on neuroendocrine levels and risk-taking.
BMC Psychol
December 2024
Center for Psychobiological Research, The Max Stern Academic College of Emek Yezreel, Emek Yezreel, Israel.
Background: The current study attempted to replicate the original findings regarding the effects of power posing on testosterone and cortisol levels, risk-taking behavior, and perceived power. We further extended the investigation by testing the effect of power posing on estradiol and progesterone levels.
Methods: A sample of 92 young adults (30 males; 32 females taking oral contraceptives; and 30 females not taking oral contraceptives who were in their midluteal phase) were randomly assigned to high-power-pose or low-power-pose conditions and asked about their feelings of power.
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