Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Durlobactam to boost the clinical utility of standard of care β-lactams against lung disease.
Antimicrob Agents Chemother
November 2024
Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
β-Lactams present several desirable pharmacodynamic features leading to the rapid eradication of many bacterial pathogens. Imipenem (IPM) and cefoxitin (FOX) are injectable β-lactams recommended during the intensive treatment phase of pulmonary infections caused by (Mab). However, their potency against Mab is many-fold lower than against Gram-positive and Gram-negative pathogens for which they were optimized, putting into question their clinical utility.
View Article and Find Full Text PDFThe Efficacy of Aloe vera Against Enterococcus faecalis as an Intracanal Medicament: A Systematic Review and Meta-Analysis.
Cureus
September 2024
Department of Microbiology, Manav Rachna Dental College, Faridabad, IND.
Calcium hydroxide (CaOH) is commonly used as an intracanal medicament due to its antimicrobial properties; its antibacterial property depends on the release of hydroxyl ions. By analyzing experimental in vitro studies related to the research question, many studies carried out bacterial inoculation on extracted human teeth or laboratory Petri dishes. This review article seeks to assess the antimicrobial efficacy of Aloe vera (AV) against in comparison to CaOH as an intracanal medicament.
View Article and Find Full Text PDFAntibiotic killing of drug-induced bacteriostatic cells.
bioRxiv
September 2024
Department of Biology, Emory University; Atlanta, Georgia, 30322, USA.
Background: There is a long-standing belief that bacteriostatic drugs are inherently antagonistic to the action of bactericidal antibiotics. This belief is primarily due to the fact that the action of most bactericidal antibiotics requires the target bacteria to be growing. Since bacteriostatic drugs stop the growth of treated bacteria, these drugs would necessarily work against one another.
View Article and Find Full Text PDFBibacillin 1: a two-component lantibiotic from .
RSC Chem Biol
September 2024
Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign Urbana IL 61822 USA +1 217 244 5360.
Here we describe bibacillin 1 - a two-component lantibiotic from . The peptides that comprise bibacillin 1 are modified by a class II lanthipeptide synthetase Bib1M producing two peptides with non-overlapping ring patterns that are reminiscent of cerecidin and the short component of the enterococcal cytolysin (CylL''), a virulence factor associated with human disease. Stereochemical analysis demonstrated that each component contains ll-methyllanthionine and dl-lanthionine.
View Article and Find Full Text PDFThe evolution of heteroresistance via small colony variants in Escherichia coli following long term exposure to bacteriostatic antibiotics.
Nat Commun
September 2024
Department of Biology, Emory University, Atlanta, GA, 30322, USA.
Traditionally, bacteriostatic antibiotics are agents able to arrest bacterial growth. Despite being traditionally viewed as unable to kill bacterial cells, when they are used clinically the outcome of these drugs is frequently as effective as when a bactericidal drug is used. We explore the dynamics of Escherichia coli after exposure to two ribosome-targeting bacteriostatic antibiotics, chloramphenicol and azithromycin, for thirty days.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!