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Exploring the relationship between electrophysiological measures of the electrically evoked auditory brainstem response and speech perception outcomes post-cochlear implantation.
Eur Arch Otorhinolaryngol
January 2025
Department of Otolaryngology, China-Japan Friendship Hospital, Beijing, China.
Objectives: This study examined the relationships between electrophysiological measures of the electrically evoked auditory brainstem response (EABR) with speech perception measured in quiet after cochlear implantation (CI) to identify the ability of EABR to predict postoperative CI outcomes.
Methods: Thirty-four patients with congenital prelingual hearing loss, implanted with the same manufacturer's CI, were recruited. In each participant, the EABR was evoked at apical, middle, and basal electrode locations.
In vivo spontaneous Ca activity in the pre-hearing mammalian cochlea.
Nat Commun
January 2025
School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.
The refinement of neural circuits towards mature function is driven during development by patterned spontaneous calcium-dependent electrical activity. In the auditory system, this sensory-independent activity arises in the pre-hearing cochlea and regulates the survival and refinement of the auditory pathway. However, the origin and interplay of calcium signals during cochlear development is unknown in vivo.
View Article and Find Full Text PDFThermally Drawn Shape and Stiffness Programmable Fibers for Medical Devices.
Adv Healthc Mater
December 2024
Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK.
Article Synopsis
- Shape Memory Polymers (SMPs) have great potential for medical applications, but their usage has been limited due to challenges in processing and production.
- This study introduces a thermal drawing technique to create Shape Memory Polymer Fibers (SMPFs) that allow for programmable stiffness and shape control, specifically designed for medical devices.
- The research explores various applications of these SMPFs in medical devices like adjustable catheters, neural interfaces, and cochlear implants, demonstrating their versatility and potential in programmable mechanical functions.
Middle ear biofilm and sudden deafness - a light and transmission electron microscopy study.
Front Neurol
December 2024
Department of Surgical Sciences, Otorhinolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden.
Background: There still exists controversy about whether the healthy human middle ear mucosa is sterile or if it may harbor a diverse microbiome. Considering the delicacy of the human round window membrane (RWM), different mechanisms may exist for avoiding inner ear pathogen invasion causing sensorineural deafness. We re-analyzed archival human RWMs using light and transmission electron microscopy after decalcification to determine if bacteria are present in clinically normal human middle ears.
View Article and Find Full Text PDFFluid-Structure Interaction Analysis of Trapezoidal and Arc-Shaped Membranes Mimicking the Organ of Corti.
Int J Numer Method Biomed Eng
January 2025
Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, Osaka, Japan.
In a previous study [H. Shintaku et al., Sensors and Actuators A: Physical 158 (2010): 183-192], an artificially developed auditory sensor device showed a frequency selectivity in the range from 6.
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