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Prevalence and Correlates of Social Isolation Among Older Adults in Subsidized Housing.
Gerontologist
January 2025
School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Background And Objectives: Social isolation is an increasing public health concern. Older residents in subsidized housing may be susceptible to isolation given high rates of chronic illness/disabilities, low income, and living alone. This cross-sectional study examined correlates of social isolation among over 3,000 older adults from nearly 100 subsidized housing communities across the US.
View Article and Find Full Text PDFPurpose: To assess the association between periodontal health and pregnancy or delivery complications in type 1 diabetic (TIDM) and non-diabetic pregnant women.
Materials And Methods: 15 TIDM and 15 non-diabetic primiparous women were enrolled in the prospective case-control study. We compared periodontal status, levels of glycosylated hemoglobin (HbA1c), gestational week of birth, birth weight of a newborn and pregnancy or delivery complications between the groups.
A hierarchical pathway for assembly of the distal appendages that organize primary cilia.
Elife
January 2025
Department of Microbiology and Immunology, Stanford University, Stanford, United States.
Distal appendages are nine-fold symmetric blade-like structures attached to the distal end of the mother centriole. These structures are critical for formation of the primary cilium, by regulating at least four critical steps: ciliary vesicle recruitment, recruitment and initiation of intraflagellar transport (IFT), and removal of CP110. While specific proteins that localize to the distal appendages have been identified, how exactly each protein functions to achieve the multiple roles of the distal appendages is poorly understood.
View Article and Find Full Text PDFProximity proteomics provides a new resource for exploring the function of Afadin and the complexity of cell-cell adherens junctions.
Biol Open
February 2025
Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
The network of proteins at the interface between cell-cell adherens junctions and the actomyosin cytoskeleton provides robust yet dynamic connections that facilitate cell shape change and motility. While this was initially thought to be a simple linear connection via classic cadherins and their associated catenins, we now have come to appreciate that many more proteins are involved, providing robustness and mechanosensitivity. Defining the full set of proteins in this network remains a key objective in our field.
View Article and Find Full Text PDFExamining priorities and investments made through the Global Financing Facility for maternal and newborn health: a sub-analysis on quality.
Glob Health Action
December 2024
London School of Hygiene & Tropical Medicine, Department of Infectious Disease Epidemiology and International Health, London, UK.
Improving quality of care could avert most of the 4.5 million maternal and neonatal deaths and stillbirths that occur each year. The Global Financing Facility (GFF) aims to catalyse the national scale-up of maternal and newborn health (MNH) interventions through focused investments.
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