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Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of MRSA.
Biomaterials
November 2017
College of Chemistry & Environmental Science, Analytical Chemistry Key Laboratory of Hebei Province, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, PR China. Electronic address:
The development of effective therapies to control methicillin-resistant Staphylococcus aureus (MRSA) infections is challenging because antibiotics can be degraded by the production of certain enzymes, for example, β-lactamases. Additionally, the antibiotics themselves fail to penetrate the full depth of biofilms formed from extracellular polymers. Nanoparticle-based carriers can deliver antibiotics with better biofilm penetration, thus combating bacterial resistance.
View Article and Find Full Text PDFRecycling antibiotics into GUMBOS: a new combination strategy to combat multi-drug-resistant bacteria.
Molecules
April 2015
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA.
The emergence of multi-drug-resistant bacteria, coupled with the lack of new antibiotics in development, is fast evolving into a global crisis. New strategies utilizing existing antibacterial agents are urgently needed. We propose one such strategy in which four outmoded β-lactam antibiotics (ampicillin, carbenicillin, cephalothin and oxacillin) and a well-known antiseptic (chlorhexidine di-acetate) were fashioned into a group of uniform materials based on organic salts (GUMBOS) as an alternative to conventional combination drug dosing strategies.
View Article and Find Full Text PDFModel of the deposition of aerosol particles in the respiratory tract of the rat. II. Hygroscopic particle deposition.
J Aerosol Med Pulm Drug Deliv
April 2013
Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), Institute for Inhalation Biology, D-85758 Neuherberg/Munich, Germany.
Background: Rats are frequently used to study the pharmacological and toxicological effects of inhaled aerosol particles. The deposition behavior of aerosol particles in airways is affected by their hygroscopic properties, which accordingly influence the results of such studies.
Method: A recently published nonhygroscopic aerosol particle deposition model for rat airways was extended with equations for hygroscopic particle growth in humid air and with a model to mimic the temperature and relative humidity conditions in the rat airways transformed from the upper human airways.
The metabolic activation of 2-aminofluorine, 4-aminobiphenyl, and benzidine by cytochrome P-450-107S1 of Pseudomonas aeruginosa.
Toxicol In Vitro
December 2007
Department of Biology, The University of Memphis, 3774 Walker Street, Memphis, TN 38152, USA.
Pseudomonas aeruginosa is an important opportunistic pathogen of the human urinary bladder. Similar to rat liver S9, the cell-free extract from P. aeruginosa caused significant increase of histidine reversion numbers with the Salmonella typhimurium tester strain TA98 in the Ames Salmonella mutagenicity assay in the presence of either 2-aminofluorene, 4-aminobiphenyl, or benzidine procarcinogens.
View Article and Find Full Text PDFBioassay for determination of fosmidomycin in plasma and urine: application for pharmacokinetic dose optimisation.
J Microbiol Methods
April 2007
Pharmacology and Toxicology Unit, Faculty of Allied Health Sciences, Thammasat University (Rangsit Campus), Paholyothin Road, Pathumthani 12121, Thailand.
A simple, sensitive, selective and reproducible method based on agar diffusion disk assay was developed for the determination of fosmidomycin and clindamycin in human plasma and urine. A disk diffusion technique was used, essentially as previously described but utilising the assay organism Enterobacter cloacae ATCC 23355 strain to seed the agar assay plates. Calibration curves were prepared from concentration response curves in plasma (0, 1, 2.
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