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Effects of Dichloromethane, Nitrate, and Sulfhemoglobin-Induced Substances on Carboxyhemoglobin Detection: A Comprehensive Review.
J Anal Toxicol
December 2024
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Institute of Forensic Sciences, Shanghai, PR China.
Carbon monoxide (CO) is a common gaseous toxin that causes severe poisoning symptoms. Accurate detection of the formation of carboxyhemoglobin (COHb) in the blood is very important for the identification of CO poisoning. In this review, the effects of exogenous toxins, including dichloromethane (DCM), nitrite and hydrogen sulfide, on the determination of COHb by spectrophotometry were summarized by comparing epidemiological data, case studies and analytical methods.
View Article and Find Full Text PDFEvaluation of the Neuroprotective Effects of Idebenone in an Experimental Carbon Monoxide Poisoning Model.
J Appl Toxicol
December 2024
Department of Emergency Medicine, School of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Carbon monoxide (CO) poisoning is among the main causes of poisoning-related mortality and morbidity, primarily affecting the central nervous system and leading to delayed neurological sequelae. Idebenone exerts antioxidant and neuroprotective effects. In this study, we aimed to evaluate the specific neuroprotective effects of idebenone against CO poisoning.
View Article and Find Full Text PDFHemolysis Index, Carboxyhemoglobin, and Methemoglobin for the Early Identification of Patients at Risk for Cardiac Surgery-Associated Acute Kidney Injury.
J Cardiothorac Vasc Anesth
December 2024
Service d'Anesthésie-Réanimation, hôpital Laënnec, Centre Hospitalier Universitaire, Nantes, France. Electronic address:
Objectives: Hemolysis is a contributor to CS-AKI. Biochemistry analyzers provide a hemolysis index to quantify in vitro hemolysis, a condition that can, for example, affect the accuracy of potassium concentration measurements. We aimed to assess whether the postoperative plasma level of the hemolysis index (HI) could aid the early recognition of patients at risk for cardiac surgery-associated acute kidney injury (CS-AKI) and also to evaluate other hemolysis indicators: plasma carboxyhemoglobin (COHb) and methemoglobin (MetHb).
View Article and Find Full Text PDFCarbon Monoxide Poisoning (Reprinted from the 2023 Hyperbaric Indications Manual 15 edition).
Undersea Hyperb Med
September 2024
Hyperbaric Medicine Division, Intermountain LDS Hospital, Salt Lake City, Utah.
Despite established exposure limits and safety standards, and the availability of carbon monoxide (CO) alarms, each year an estimated 50,000 people in the United States visit emergency departments for CO poisoning. Carbon monoxide poisoning can occur from brief exposures to high levels of CO or from longer exposures to lower levels. If the CO exposure is sufficiently high, unconsciousness and death occur quickly, and without symptoms.
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