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Characterization, adsorption kinetic and in vitro release behavior of curcumin loaded with porous mannitol and porous lactose: Template agent method vs. Pore-forming agent method.
Food Res Int
January 2025
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Jiangxi University of Chinese Medicine, Nanchang 330004, China. Electronic address:
Polyvinylpyrrolidone K30 was used as the templating agent, and ammonium bicarbonate was used as the pore-forming agent to make porous mannitol and porous lactose by the template and pore-forming agent method, respectively. Compared with the template method, the porous particles prepared by the pore-forming agent method have larger pore diameter (320.276 nm and 250.
View Article and Find Full Text PDFOptimized chelator and nanoparticle strategies for high-activity Pd-loaded biodegradable brachytherapy seeds.
EJNMMI Radiopharm Chem
December 2024
The Hevesy Laboratory, DTU Health Technology, Frederiksborgvej 399, 4000, Roskilde, Denmark.
Background: Brachytherapy (BT) is routinely used in the treatment of various cancers. Current BT relies on the placement of large sources of radioactivity at the tumor site, requiring applicators that may cause local traumas and lesions. Further, they suffer from inflexibility in where they can be placed and some sources reside permanently in the body, causing potential long-term discomfort.
View Article and Find Full Text PDFCombination of DMDD with Nanoparticles Effective Against Diabetic Kidney Disease in vitro.
Int J Nanomedicine
November 2024
The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People's Republic of China.
Purpose: 2-Dodecyl-6-methoxy-2,5-diene-1,4-cyclohexanedione (DMDD), isolated from . root, has demonstrated the potential to reduce blood sugar levels. However, DMDD has poor solubility and bioavailability.
View Article and Find Full Text PDFCanonical Correlation of Milk Composition Parameters and Blood Biomarkers in High-Producing Dairy Cows During Different Lactation Stages.
Animals (Basel)
November 2024
Institute of Applied Biology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Tr. A. Hlinku 2, 949 76 Nitra, Slovakia.
This study explores milk composition and blood markers in cows across lactation stages. Holstein cows were divided into four groups: beginning of lactation (BL; = 21), peak of lactation (PL; = 21), middle of lactation (ML; = 21), and end of lactation (EL; = 20). Blood (1 × 15 mL) and milk samples (1 × 100 mL) were collected for biomarker analysis.
View Article and Find Full Text PDFMajor alteration of lung microbiome and the host responses in critically ill COVID-19 patients with high viral load.
Sci Rep
November 2024
Unisabana Center of Translational Science, Universidad de La Sabana, Campus Puente del Común, KM 7.5 Autopista Norte de Bogotá, Chia, Colombia.
Article Synopsis
- Patients with COVID-19 on ventilators have a higher risk of developing ventilator-associated pneumonia (VAP), which can lead to increased healthcare costs and worse outcomes.* -
- This study analyzed the lung microbiome and immune responses in mechanically ventilated COVID-19 patients to understand the mechanisms leading to VAP, comparing samples taken shortly after intubation and 72 hours later.* -
- Results showed differences in the microbiome related to VAP, along with higher viral loads and unique metabolic changes in patients who developed VAP, highlighting the complex interactions between microbiota, viral response, and inflammation.*
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