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The Antimicrobial Activity of Zinc Oxide Nanoparticles incorporated into Alginate Impression Material: An Study.
J Int Soc Prev Community Dent
December 2024
College of Dentistry, Mosul University, Mosul, Iraq.
Background And Aim: In dental clinics, disinfecting alginate impression materials is a critical practice to prevent cross-infection. Recently, zinc oxide nanoparticles (ZnO NPs) have been explored for their potential antimicrobial properties, making them promising additives for dental materials. This study investigates the antimicrobial activity of ZnO NPs incorporated into alginate impression materials and assesses the impact on material flow.
View Article and Find Full Text PDFSynthesis, Characterization, and Antimicrobial Activity of Urea-Containing α/β Hybrid Peptides against and Methicillin-Resistant .
ACS Omega
January 2025
Infectious Diseases Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, Jammu and Kashmir 180001, India.
The insertion of β-amino acids and replacement of the amide bond with a urea bond in antimicrobial peptide sequences are promising approaches to enhance the antibacterial activity and improve proteolytic stability. Herein, we describe the synthesis, characterization, and antibacterial activity of short αβ cationic hybrid peptides LA-Orn-βAcc-PEA, ; LA-Lys-βAcc-PEA, ; and LA-Arg-βAcc-PEA, in which a C12 lipid chain is conjugated at the N terminus of peptide through urea bonds. Further, we evaluated all the peptides against both and methicillin-resistant (MRSA) and their multidrug resistant (MDR) clinical isolates.
View Article and Find Full Text PDFextracts mediated synthesis of copper oxide nanoparticles and their biological applications.
Heliyon
January 2025
Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
With the passage of time there is enormous development in the field of science and technology, however, human health remained the utmost concern. There are different strategies that helps us to treat various diseases but they have adverse reactions on our bodies. Nanobiotechnology is the advanced field consisting of new techniques and fabrication procedures for nanostructures for making drugs more effective against diseases in less time.
View Article and Find Full Text PDFDose Evaluation and Optimization of Amoxicillin in Children Treated for Lyme Disease.
J Clin Pharmacol
January 2025
Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Amoxicillin is commonly used to treat erythema migrans in the first stage of Lyme disease in children, with a recommended dose of 50 mg/kg/day, administered three times a day (q8h). This model-based simulation study aimed to determine whether splitting the same daily dose into two administrations (q12h) would provide comparable drug exposure. A pharmacokinetic model suitable for a pediatric population (age: 1 month to 18 years, weight: 4-80 kg) was selected through a literature review.
View Article and Find Full Text PDFProtective effect of curcumin-loaded zeolitic imidazolate framework-8-based pH-responsive drug delivery system against Staphylococcus aureus infection.
Microb Pathog
January 2025
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China; Animal Disease Prevention and Control Center of Ningxia Hui Autonomous Region, Yinchuan 750001, Ningxia, P. R. China. Electronic address:
Mastitis, generally caused by pathogenic microorganisms, is a serious disease in dairy farming. Staphylococcus aureus (S. aureus) is one of the main pathogens that induces mastitis in dairy cows.
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