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Neonatal Pain Management: Is There An Endocrinal Response?
Endocr Metab Immune Disord Drug Targets
January 2025
Department of Pediatrics, El Menshawy General Hospital, Tanta, Egypt.
Neonates exhibit pain responses characterized by various endocrinal changes, including alterations in cortisone and oxytocin serum levels, as well as physiological and emotional reactions. The administration of neonatal pain management leads to the normalization of endocrine hormones, including cortisone and oxytocin, which are affected by the presence of neonatal pain. Diagnosing neonatal pain is complex; however, effective management is essential.
View Article and Find Full Text PDFHigh- versus Low-dose Oxytocin Regimens for Labor Augmentation: A Systematic Review and Meta-analysis.
Am J Obstet Gynecol MFM
January 2025
Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, DE; Delaware Center for Maternal Fetal Medicine, Newark, DE.
Objective: To assess whether high- versus low-dose oxytocin regimens for labor augmentation are associated with differential risk for low Apgar score, neonatal acidosis, and other adverse labor outcomes.
Data Sources: We searched electronic databases (MEDLINE, EMBASE, the Cochrane Library, CINAHL, Scopus, ClinicalTrials.gov) from inception up to March 2024 using combinations of the following keywords: "oxytocin," "oxytocin regimen," "oxytocin protocol," "oxytocin dosage," "active management," "high dose protocol," "low dose protocol," "augmentation of labor.
Neurobiological mechanisms of antidepressant properties of psilocybin: A systematic review of blood biomarkers.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands.
Psilocybin represents a novel therapeutic approach for individuals with major depressive disorder (MDD) who do not respond to conventional antidepressant treatment. Investigating the influence of psilocybin on the pathophysiological processes involved in MDD could enhance our neurobiological understanding of the presumed antidepressant action mechanism. This systematic review aims to summarize the results of human studies investigating changes in blood-based biomarkers of MDD to guide future research on potentially relevant analytes that could be monitored in clinical trials.
View Article and Find Full Text PDFHow Do Common Marmosets Maintain the Balance Between Response Execution and Action Inhibition?
Am J Primatol
January 2025
Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Socio-dynamic situations require a balance between response execution and action inhibition. Nonadaptive imbalance between response inhibition and execution exists in neurodevelopmental and neuropsychological disorders. To investigate the underlying neural mechanisms of cognitive control and the related deficits, comparative studies in human and nonhuman primates are crucial.
View Article and Find Full Text PDFAssociation between combined use of epidural analgesia and oxytocin administration during labor and offspring outcomes: a narrative review and proposal.
Nagoya J Med Sci
November 2024
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Studies have suggested that the administration of epidural analgesia (Epi) and oxytocin (OT) during labor affects offspring outcomes. However, the effects of their combined use remain unclear. This article aimed to review the outcomes of offspring exposed to Epi and OT, identify research gaps, and discuss future research directions.
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