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Frequency of in dogs from the municipality of Veracruz, Mexico.
Vet Res Forum
December 2024
Department of Veterinary Microbiology, Faculty of Veterinary Medicine and Animal Science, University of Veracruz, Veracruz, Mexico.
Infectious canine cyclic thrombocytopenia or canine anaplasmosis is an infectious disease caused by . In Mexico, cases of human infection have been reported. The present cross-sectional study aimed to determine the frequency of infection in the municipality of Veracruz, Mexico, by nested polymerase chain reaction method.
View Article and Find Full Text PDFA complex case of disseminated histoplasmosis triggering hemophagocytic lymphohistiocytosis in a patient with lupus.
Radiol Case Rep
January 2025
Department of Family Medicine, St. Luke's University Health Network, Warren, NJ, USA.
Disseminated histoplasmosis is a rare yet serious fungal infection that primarily affects individuals with compromised immune systems. While it is widely known for its endemicity in the Midwest region of the USA, recent studies have indicated a noteworthy increase in sporadic cases, suggesting a widening of the endemic region for the pathology. This report describes a case of disseminated histoplasmosis in a 39-year-old female with a history of lupus, hypertension, anxiety, asthma, idiopathic edema, and fibromyalgia from a nonendemic region, who presented with cyclic fevers of unknown origin, peripheral edema, and oral sores.
View Article and Find Full Text PDFFirst-in-Human Dose-Escalation Study of the First-in-Class PDE3A-SLFN12 Complex Inducer BAY 2666605 in Patients with Advanced Solid Tumors Coexpressing SLFN12 and PDE3A.
Clin Cancer Res
December 2024
Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, Houston, Texas.
Article Synopsis
- - The study aimed to assess the safety and pharmacological effects of BAY 2666605, a new drug designed to trigger a response in cancer cells by promoting the interaction of two proteins, PDE3A and SLFN12.
- - In a first-in-human trial, five patients with specific tumor characteristics received the drug, but the most notable adverse effect was severe thrombocytopenia (low platelet count), affecting three patients, leading to challenges in determining a safe dosage.
- - Ultimately, due to the severe side effects and the lack of positive treatment responses, the trial was halted, as the drug could not establish a therapeutic dose without causing significant safety issues.
Malaria in Appalachia? A Rare Case of Plasmodium vivax in an Adolescent Exchange Student From South Korea.
Cureus
September 2024
Pediatrics, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Article Synopsis
- * Malaria can be transmitted by mosquitos in endemic areas and, despite being rare in the U.S., can occur in returning travelers, posing severe health risks if not promptly treated.
- * A case study of a 17-year-old South Korean traveler illustrates the importance of thorough clinical assessment, revealing malaria despite a negative rapid test, leading to successful treatment and no lasting effects.
Case report: Comprehensive clinical, pathological and genetic investigations to decipher the background of cyclic thrombocytopenia.
Pathol Oncol Res
October 2024
Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Article Synopsis
- Cyclic thrombocytopenia (CTP) is a rare blood disorder where patients experience fluctuating platelet counts, and its underlying causes are not well understood.
- In a recent study, a 41-year-old woman with a 22-year history of CTP underwent extensive tests including bone marrow biopsy and genetic analysis to explore possible physiological defects associated with the disease.
- The results revealed normal blood cell production with some abnormal platelet characteristics, a genetic variant linked to a different blood disorder, and no autoimmune activity, adding valuable information to the limited understanding of CTP.
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