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Department of Cardiovascular, The First Affiliated Hospital of Dalian Medical University, 116014 Dalian, Liaoning, China.
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The Association of the Cancer Inflammation Prognostic Index with Microsatellite Instability, Tumor Budding and Prognosis in Colorectal Adenocarcinoma.
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Department of General Surgery, Başakşehir Çam and Sakura City Hospital, 34480 İstanbul, Turkey.
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Prognostic Impact and Safety of Ketorolac Tromethamine in Tibial Plateau Fracture Patients Undergoing Open Reduction and Internal Fixation.
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Department of Orthopedics, Dongtai People's Hospital, 224200 Yancheng, Jiangsu, China.
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Clinical Outcomes and Complications of Total Knee Arthroplasty with Posterior-Stabilized and Cruciate-Retaining Prostheses in Osteoarthritis Patients with Valgus Deformity.
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Department of Orthopedic Trauma, The Affiliated Hospital of Gansu University of Traditional Chinese Medicine, 730020 Lanzhou, Gansu, China.
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Surgery of the Primary Tumor in de novo Metastatic Breast Cancer: A Palliative Approach or a Potential Survival Game-Changer?
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Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Approximately 5-10% of primary breast cancer cases present as de novo stage IV disease, characterized by distant metastases at diagnosis. Traditionally, systemic therapies such as chemotherapy, endocrine therapy and targeted treatments have formed the cornerstone of treatment for metastatic breast cancer (MBC), focusing on disease control, symptom palliation and quality of life improvement. While systemic therapies remain crucial, the role of local treatments, particularly surgery for the primary tumor, is increasingly debated.
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