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Clinical Significance of Factor XIII Activity and Monocyte-Derived Microparticles in Cancer Patients.
Vasc Health Risk Manag
June 2020
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Background: The aim was to evaluate factor XIII activity (FXIIIa) and monocyte-derived microparticles (MDMPs) in cancer patients.
Methods: In total, 138 cancer patients (31 malignant lymphomas, 39 multiple myelomas, and 68 lung cancers) were analyzed. We measured various biomarkers including FXIIIa and MDMPs.
Cytokine Profile, Apoptosis, Glucocorticoid Receptor, and P-glycoprotein Expression Before and After Megadose Methylprednisolone Treatment in Children With Acute Immune Thrombocytopenia.
J Pediatr Hematol Oncol
October 2019
Department of Hematology, Anadolu Sağlik Merkezi (Private Hospital/In affiliation with Johns Hopkins Medicine), Gebze, Turkey.
Objective: Immune thrombocytopenia (ITP) is an autoimmune disease, and it has become evident that T lymphocytes play an important role in the pathogenesis of ITP. We investigated the role of T helper (Th) intracellular IL-2, IL-4, IL-6, IFN-γ, and T lymphocyte apoptosis in the pathogenesis of acute ITP and the effect of glucocorticoid treatment on cytokine profile. We investigated also P-glycoprotein (P-gp) and glucocorticoid receptor (GCR) expression as a possible mechanism for glucocorticoid resistance.
View Article and Find Full Text PDFRetrospective evaluation of children with immune thrombocytopenic purpura and factors contributing to chronicity.
Pediatr Neonatol
August 2019
University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Department of Hematology, Ankara, Turkey.
Objective: Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia children. The aim of this retrospective study is to describe presenting features and clinical characteristics of ITP and evaluate clinical course, treatment modalities, and complications and determine the effects of preceding infection history, age, gender, treatment modality, and admission platelet count on chronicity.
Method: Two hundred and eleven patients who were diagnosed ITP and followed-up in Department of Pediatric Hematology, Ankara Children Hematology Oncology Education and Research Hospital between January 2008 and September 2012 were included.
Effects of normoxic and hypoxic exercise regimens on monocyte-mediated thrombin generation in sedentary men.
Clin Sci (Lond)
August 2015
†Heart Failure Center, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Exercise and hypoxia paradoxically modulate vascular thrombotic risks. The shedding of procoagulant-rich microparticles from monocytes may accelerate the pathogenesis of atherothrombosis. The present study explores the manner in which normoxic and hypoxic exercise regimens affect procoagulant monocyte-derived microparticle (MDMP) formation and monocyte-promoted thrombin generation (TG).
View Article and Find Full Text PDFRelationship between magnetic resonance angiography-diffusion-weighted imaging mismatch and clinical outcome in endovascular treatment for acute ischemic stroke: subgroup analysis of the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism--Japan Registry.
J Stroke Cerebrovasc Dis
July 2014
Department of Neurology, Saitama Medical University International Medical Center, Saitama, Japan.
Background: The presence or absence of the penumbra area is important when performing reperfusion therapy in patients with acute ischemic stroke. As a predictor of this penumbra area, magnetic resonance angiography (MRA)-diffusion-weighted imaging (DWI) mismatch is attracting attention. The usefulness of MRA-DWI mismatch (MDM) using the DWI-Alberta Stroke Program Early Computed Tomography Score (ASPECTS) in endovascular treatment (EVT) of patients with cerebral large vessel occlusion was evaluated.
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