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A Rare Case of Juvenile Granulosa Cell Tumor in a Premenarchal Female: Clinical Presentation, Diagnosis, and Management.
Cureus
December 2024
2nd Pediatric Surgery Department, Athens Children's Hospital P&A Kyriakou, Athens, GRC.
Juvenile granulosa cell tumors (JGCTs), a rare type of ovarian tumor, are predominantly seen in premenarchal girls. We report a case of a 4.5-year-old girl with precocious puberty and a left ovarian JGCT, confirmed through imaging and histopathology.
View Article and Find Full Text PDFHuman Dermal Microvascular Arterial and Venous Blood Endothelial Cells and Their Use in Bioengineered Dermo-Epidermal Skin Substitutes.
Small Methods
January 2025
Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Lenggstrasse 30, Zurich, 8008, Switzerland.
The bioengineering of vascular networks is pivotal to create complex tissues and organs for regenerative medicine applications. However, bioengineered tissues comprising an arterial and venous plexus alongside a lymphatic capillary network have not been explored yet. Here, scRNA-seq is first employed to investigate the arterio-venous endothelial cell marker patterning in human fetal and juvenile skin.
View Article and Find Full Text PDFSonographic Features of Juvenile Fibroadenoma in Children-a Retrospective Study.
Curr Med Imaging
January 2025
Department of Ultrasound, Peking University First Hospital, Beijing 100034, China.
Aims: Studies specifically examining the sonographic features of juvenile fibroadenoma in the pediatric population have not been documented. We aimed to analyze sonograms of juvenile fibroadenoma in children.
Subjects And Methods: Patients aged ≤ 18 years who underwent breast ultrasound examinations at our department and had pathologically proven juvenile fibroadenoma from September 2002 to January 2022 were included in this study.
Systemic Inflammatory Diseases in Children with Sickle Cell Disease: A French Multicenter Observational Study on Diagnostic and Therapeutic Issues.
Pediatr Blood Cancer
January 2025
Pediatrics Department, Jean Verdier Hospital, APHP, Bondy, France.
Background: Systemic inflammatory diseases (SIDs) have been reported in patients with sickle cell disease (SCD), but clinical data in children are scarce.
Objectives: To identify clinical and laboratory features at diagnosis of SID in children with SCD and to describe their evolution.
Methods: Data from children with SCD and SIDs were retrospectively collected in a French multicenter study from 1991 to 2018.
Ecometabolomics of Loggerhead Sea Turtles (): The Impact of Age on Metabolomic Profiles.
Int J Mol Sci
January 2025
Department of Animal and Veterinary Sciences, Aarhus University, Blichers Alle 20, DK-8830 Tjele, Denmark.
To investigate the impact of age on the metabolomic profile of loggerhead sea turtles (), this study analyzed 100 plasma samples of individuals across two age groups-50 post-hatchlings and 50 juveniles-from various locations along the Mediterranean coastline. Both targeted and untargeted metabolomic analyses were performed on the samples. Our results demonstrated a significant age-related effect on the metabolomic profiles in both analyses.
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