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Comparative study of polymeric nanoparticles and traditional agents in dental implant decontamination.
J Appl Biomater Funct Mater
January 2025
Faculty of Dentistry, Department of Periodontics, Complutense University of Madrid, Madrid, Spain.
Peri-implant diseases, such as peri-implantitis, affect up to 47% of dental implant recipients, primarily due to biofilm formation. Current decontamination methods vary in efficacy, prompting interest in polymeric nanoparticles (NPs) for their antimicrobial and protein-specific cleaning properties. This study evaluated the efficacy of polymeric nanoparticles (NPs) in decontaminating titanium dental implants by removing proteinaceous pellicle layers and resisting recontamination.
View Article and Find Full Text PDFsynergistically supports systemic plant defense response in against .
Front Plant Sci
January 2025
Plant Biochemistry and Physiology, Bielefeld University, Bielefeld, Germany.
The network of antagonistic, neutral, and synergistic interactions between (micro)organisms has moved into the focus of current research, since in agriculture, this knowledge can help to develop efficient biocontrol strategies. Applying the nematophagous fungus as biocontrol agent to manage the root-knot nematode is a highly promising strategy. To gain new insight into the systemic response of plants to a plant-parasitic nematode and a nematophagous fungus, was inoculated with and/or and subjected to transcriptome and metabolome analysis of leaves.
View Article and Find Full Text PDFSMAP3-ID for Identification of Endogenous Protein-Protein Interactions Reveals Regulation of Mitochondrial Activity by Lamins.
JACS Au
January 2025
Program in Chemical Biology, Department of Chemical Physiology and Biochemistry, Proteomics Shared Resources, Knight Cancer Institute, Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, United States.
Proteins regulate biological functions through the formation of distinct protein complexes. Identification and characterization of these protein-protein interactions are critical to deciphering their mechanism of action. Different antibody-based or cross-linking-based methods have been developed to identify the protein-protein interactions.
View Article and Find Full Text PDFChemical Reactions on a Single Linear Chain Show Cooperativity.
JACS Au
January 2025
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Key Laboratory of Polymer Chemistry & Physics, Beijing 100871, People's Republic of China.
Individual molecules dissolved in a dilute solution are usually considered not to correlate with each other as they undergo chemical reactions due to the mismatch of the diffusion and reaction time scales. Recent studies suggest otherwise, especially for reactions involving macromolecules. With selenopolypeptides as a model system, we used ensemble measurements and single-molecule direct imaging to investigate the correlation between physically constrained chemical reaction sites on a linear polymer chain and the coupling effects between conformation changes and reaction kinetics.
View Article and Find Full Text PDFSimultaneous Live Mapping of pH and Hydrogen Peroxide Fluctuations in Autophagic Vesicles.
JACS Au
January 2025
Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India.
Hydrogen peroxide (HO) plays a critical role in the regulation and progress of autophagy, an essential recycling process that influences cellular homeostasis and stress response. Autophagy is characterized by the formation of intracellular vesicles analogous to recycle "bags" called autophagosomes, which fuse with lysosomes to form autolysosomes, eventually ending up as lysosomes. We have developed two novel autophagic vesicle-targeted peptide-based sensors, for HO and for pH, to simultaneously track HO and pH dynamics within autophagic vesicles as autophagy advances.
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